PMID- 17339192
OWN - NLM
STAT- MEDLINE
DCOM- 20070425
LR  - 20190608
IS  - 1592-8721 (Electronic)
IS  - 0390-6078 (Linking)
VI  - 92
IP  - 3
DP  - 2007 Mar
TI  - The translocations t(6;18;11)(q24;q21;q21) and t(11;14;18)(q21;q32;q21) lead to a 
      fusion of the API2 and MALT1 genes and occur in MALT lymphomas.
PG  - 405-9
AB  - So far, only one variant translocation of the t(11;18)(q21;q21), the t(11;12;18) 
      (q21;q13;q21), has been reported. We herein describe two new variant 
      translocations, the t(6;18;11)(q24;q21;q21) and the t(11;14;18)(q21;q32;q21), 
      occurring in mucosa-associated lymphoid tissue (MALT) lymphomas. In both cases, 
      fluorescence in situ hybridization (FISH) and reverse transcriptase polymerase 
      chain reaction (RT-PCR) revealed the presence of an 5'API2-3'MALT1 fusion 
      product, encoded on the derivative chromosome 11. Exon 7 of API2 was fused with 
      exon 5 of MALT1 in the t(11;14;18) and with exon 8 of MALT1 in the t(6;18;11). 
      FISH revealed the involvement of the immunoglobulin locus in the t(11;14;18). 
      Rapid amplification of cDNA ends (RACE)-PCR to detect the involved partner gene 
      on 6q showed exclusively wild-type API2 and MALT1 sequences.
FAU - Murga Penas, Eva M
AU  - Murga Penas EM
AD  - University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
FAU - Callet-Bauchu, Evelyne
AU  - Callet-Bauchu E
FAU - Ye, Hongtao
AU  - Ye H
FAU - Hinz, Kristina
AU  - Hinz K
FAU - Albert, Nadine
AU  - Albert N
FAU - Copie-Bergman, Christiane
AU  - Copie-Bergman C
FAU - Gazzo, Sophie
AU  - Gazzo S
FAU - Berger, Francoise
AU  - Berger F
FAU - Salles, Gilles
AU  - Salles G
FAU - Bokemeyer, Carsten
AU  - Bokemeyer C
FAU - Du, Ming-Qing
AU  - Du MQ
FAU - Dierlamm, Judith
AU  - Dierlamm J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
RN  - 0 (API2-MALT1 fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Aged
MH  - Chromosomes, Human, Pair 11/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 14/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 18/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 6/*genetics/ultrastructure
MH  - Computer Systems
MH  - Exons/*genetics
MH  - Genes, Immunoglobulin
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lung Neoplasms/genetics
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stomach Neoplasms/genetics
MH  - *Translocation, Genetic
EDAT- 2007/03/07 09:00
MHDA- 2007/04/26 09:00
CRDT- 2007/03/07 09:00
PHST- 2007/03/07 09:00 [pubmed]
PHST- 2007/04/26 09:00 [medline]
PHST- 2007/03/07 09:00 [entrez]
AID - 10.3324/haematol.10268 [doi]
PST - ppublish
SO  - Haematologica. 2007 Mar;92(3):405-9. doi: 10.3324/haematol.10268.