PMID- 17341859
OWN - NLM
STAT- MEDLINE
DCOM- 20070516
LR  - 20070307
IS  - 1018-8665 (Print)
IS  - 1018-8665 (Linking)
VI  - 214
IP  - 2
DP  - 2007
TI  - Three retinoid X receptor gene polymorphisms in plaque psoriasis and psoriasis 
      guttata.
PG  - 118-24
AB  - AIM: Polymorphisms in retinoid X receptors (RXRs) are very interesting from the 
      point of view of a possible association of their variability with psoriasis. 
      METHODS: A total of 293 patients with plaque psoriasis, 82 patients with 
      psoriasis guttata and 202 control subjects were enrolled in this study focused on 
      3 polymorphisms in RXRA and RXRB gene associations. RESULTS: A marginally 
      significant increase in AA allelic frequency of the RXRA A39526AA polymorphism in 
      plaque psoriatic men compared to healthy men was proved. In women with psoriasis 
      guttata, the higher risk for genotypes AA and TT in the RXRB 3'+140A/T 
      polymorphism compared to healthy women was identified (p(corr) = 0.01). The 
      genotypes A/A and AA/AA are more frequent in plaque psoriasis patients with a 
      positive family history of psoriasis compared to the patients with a negative 
      family history of psoriasis (p(corr) = 0.02). The A/A genotype is more frequent 
      in patients with plaque psoriasis and repeated tonsillitis/tonsillectomy (p = 
      0.02). In the RXRB polymorphism, no genotype TT is observed in patients with 
      psoriasis guttata with a positive personal history of repeated tonsillitis 
      (p(corr) = 0.001). CONCLUSION: Individual gene characteristics of patients with 
      psoriasis improve the possibilities of pharmacotherapy using pharmacogenomic 
      approaches which could be further stratified in future according to the subtypes 
      of psoriasis.
CI  - Copyright 2007 S. Karger AG, Basel.
FAU - Vasku, Vladimir
AU  - Vasku V
AD  - 1st Department of Dermatology, St. Ann's Faculty Hospital, Masaryk University, 
      Brno, Czech Republic. vladimir.vasku@fnusa.cz
FAU - Bienertova Vasku, Julie
AU  - Bienertova Vasku J
FAU - Pavkova Goldbergova, Monika
AU  - Pavkova Goldbergova M
FAU - Vasku, Anna
AU  - Vasku A
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
RN  - 0 (RNA, Messenger)
RN  - 0 (Retinoid X Receptor alpha)
RN  - 0 (Retinoid X Receptor beta)
RN  - 0 (Retinoid X Receptors)
RN  - 11002-13-4 (Angiotensinogen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiotensinogen/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Psoriasis/classification/*genetics/pathology
MH  - RNA, Messenger/genetics
MH  - Retinoid X Receptor alpha/genetics
MH  - Retinoid X Receptor beta/genetics
MH  - Retinoid X Receptors/*genetics
MH  - Tonsillitis/genetics
EDAT- 2007/03/08 09:00
MHDA- 2007/05/17 09:00
CRDT- 2007/03/08 09:00
PHST- 2006/04/07 00:00 [received]
PHST- 2006/07/28 00:00 [accepted]
PHST- 2007/03/08 09:00 [pubmed]
PHST- 2007/05/17 09:00 [medline]
PHST- 2007/03/08 09:00 [entrez]
AID - 000098569 [pii]
AID - 10.1159/000098569 [doi]
PST - ppublish
SO  - Dermatology. 2007;214(2):118-24. doi: 10.1159/000098569.