PMID- 17342255
OWN - NLM
STAT- MEDLINE
DCOM- 20070503
LR  - 20200403
IS  - 1672-9145 (Print)
IS  - 1745-7270 (Electronic)
IS  - 1672-9145 (Linking)
VI  - 39
IP  - 3
DP  - 2007 Mar
TI  - Possible role of histone H1 in the regulation of furin-dependent proprotein 
      processing.
PG  - 173-80
AB  - Histone H1 and its C-terminal lysine rich fragments were recently found to be 
      potent inhibitors of furin, a mammalian proprotein convertase. However, its role 
      in the regulation of furin-dependent proprotein processing remains unclear. Here 
      we report that histone H1 efficiently blocks furin-dependent pro-von Willebrand 
      factor (pro-vWF) processing in a dose-dependent manner. Coimmunoprecipitation and 
      immunofluorescence studies confirmed that histone H1 could interact with furin, 
      and the interaction mainly took place on the cell surface. We noted that histone 
      H1 was released from cells undergoing necrosis and apoptosis induced by H(2)O(2). 
      Our findings suggested that histone H1 might be involved in extracellular and/or 
      intracellular furin regulation.
FAU - Han, Jinbo
AU  - Han J
AD  - Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Graduate 
      School of the Chinese Academy of Sciences, Shanghai, China.
FAU - Gu, Jianxin
AU  - Gu J
FAU - Chi, Chengwu
AU  - Chi C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Acta Biochim Biophys Sin (Shanghai)
JT  - Acta biochimica et biophysica Sinica
JID - 101206716
RN  - 0 (Histones)
RN  - 0 (Protein Precursors)
RN  - 0 (von Willebrand Factor)
RN  - 0 (von Willebrand factor propolypeptide)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 3.4.21.75 (Furin)
SB  - IM
MH  - Animals
MH  - Apoptosis/physiology
MH  - Cell Line
MH  - Cricetinae
MH  - Furin/*metabolism
MH  - HeLa Cells
MH  - Histones/*metabolism
MH  - Humans
MH  - Hydrogen Peroxide/toxicity
MH  - Necrosis
MH  - Protein Precursors/metabolism
MH  - Protein Processing, Post-Translational
MH  - Subcellular Fractions/metabolism
MH  - von Willebrand Factor/metabolism
PMC - PMC7109942
EDAT- 2007/03/08 09:00
MHDA- 2007/05/04 09:00
PMCR- 2007/03/01
CRDT- 2007/03/08 09:00
PHST- 2007/03/08 09:00 [pubmed]
PHST- 2007/05/04 09:00 [medline]
PHST- 2007/03/08 09:00 [entrez]
PHST- 2007/03/01 00:00 [pmc-release]
AID - 10.1111/j.1745-7270.2007.00267.x [doi]
PST - ppublish
SO  - Acta Biochim Biophys Sin (Shanghai). 2007 Mar;39(3):173-80. doi: 
      10.1111/j.1745-7270.2007.00267.x.