PMID- 17342698
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20070307
IS  - 0393-5590 (Print)
IS  - 0393-5590 (Linking)
VI  - 24
IP  - 1
DP  - 2007 Jan-Feb
TI  - [MEN type 1 and chronic renal failure: a rarely reported association].
PG  - 79-82
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN 1), or Wermer's syndrome, is 
      a rare autosomal dominant genetic syndrome characterized by tumors or hyperplasia 
      involving the pituitary, parathyroid, and pancreatic islet cells. Association 
      between MEN 1 and nephrocalcinosis is well known, though data published in 
      medical literature regarding Wermer's syndrome and chronic renal failure relation 
      are still rare. CASE: A 70-year-old Caucasian female patient had a history of 
      primitive hyperparathyroidism, prolactinoma, glucagonoma, adrenal adenoma and 
      pulmonary neuroendocrine neoplasia. She presented at our clinic first when she 
      was 62 years old because of hypertension, nephrolithiasis (calcium oxalate) and 
      diabetes mellitus treated with oral agents. During the eight-year follow-up she 
      developed chronic renal failure (serum creatinine 1.8 mg/dL, glomerular clearance 
      35 mL/min) and partial thrombosis of abdominal aortic wall. CONCLUSIONS: Although 
      the association between renal failure and MEN 1 is rarely reported, patients 
      affected by Wermer's syndrome have several risk factors of decreasing renal 
      function such as hypertension, nephrolithiasis and diabetes mellitus. Moreover, 
      hyperparathyroidism in MEN 1 is clinically similar to the kidney failure 
      condition; indeed, diffuse hyper-plasia of more than one gland is common. Vitamin 
      D should not be administered to these patients. Nephrologists should be involved 
      in MEN 1 follow-up, with the aim to prevent kidney failure development by 
      correcting risk factors.
FAU - Molino, C
AU  - Molino C
AD  - U.O. di Nefrologia e Dialisi, Arcispedale S. Anna, Ferrara - Italy.
FAU - Fabbian, F
AU  - Fabbian F
FAU - Russo, G
AU  - Russo G
FAU - Cantelli, S
AU  - Cantelli S
FAU - Bortot, A
AU  - Bortot A
FAU - Galdi, A
AU  - Galdi A
FAU - Catizone, L
AU  - Catizone L
LA  - ita
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - MEN tipo 1 ed insufficienza renale: una associazione poco conosciuta.
PL  - Italy
TA  - G Ital Nefrol
JT  - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di 
      nefrologia
JID - 9426434
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*complications
MH  - Multiple Endocrine Neoplasia Type 1/*complications
EDAT- 2007/03/08 09:00
MHDA- 2010/03/02 06:00
CRDT- 2007/03/08 09:00
PHST- 2007/03/08 09:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
PHST- 2007/03/08 09:00 [entrez]
PST - ppublish
SO  - G Ital Nefrol. 2007 Jan-Feb;24(1):79-82.