PMID- 17343559
OWN - NLM
STAT- MEDLINE
DCOM- 20070530
LR  - 20070308
IS  - 1044-5463 (Print)
IS  - 1044-5463 (Linking)
VI  - 17
IP  - 1
DP  - 2007 Feb
TI  - Metyrosine in psychosis associated with 22q11.2 deletion syndrome: case report.
PG  - 115-20
AB  - This report describes the use of metyrosine (Demser) in an adolescent male with 
      psychosis associated with the 22q11.2 deletion syndrome (velocardiofacial 
      syndrome; VCFS), diagnosed by fluorescence in situ hybridization (FISH). He 
      presented with multiple features of 22q11.2 deletion syndrome, including 
      ventricular septal defect, palatal abnormalities, speech and motor delays, 
      attention deficits, mood lability, and psychosis. After a failed trial of an 
      atypical antipsychotic to address the psychosis, metyrosine was initiated, with 
      significant reduction of psychotic symptoms and mood lability. Metyrosine 
      treatment allowed this youth to live at home and to attend school, after months 
      of recurrent psychiatric hospitalizations. The successful treatment of metyrosine 
      for psychosis associated with VCFS represents a first in psychiatry, where a 
      known biochemical abnormality in a psychiatric disorder was corrected by a 
      treatment that targets the biochemical pathway, leading to reduction of 
      psychiatric symptoms and improvement of functioning.
FAU - Carandang, Carlo G
AU  - Carandang CG
AD  - Dalhousie University, Halifax, Nova Scotia, Canada. 
      carlo.carandang@iwk.nshealth.ca
FAU - Scholten, Monique C
AU  - Scholten MC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Child Adolesc Psychopharmacol
JT  - Journal of child and adolescent psychopharmacology
JID - 9105358
RN  - 0 (Enzyme Inhibitors)
RN  - 658-48-0 (alpha-Methyltyrosine)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
SB  - IM
MH  - Adolescent
MH  - Ambulatory Care
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 22
MH  - DiGeorge Syndrome/*genetics/psychology
MH  - Enzyme Inhibitors/*therapeutic use
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Patient Readmission
MH  - Psychotic Disorders/diagnosis/*drug therapy/*genetics/psychology
MH  - Social Behavior
MH  - Tyrosine 3-Monooxygenase/*antagonists & inhibitors
MH  - alpha-Methyltyrosine/*therapeutic use
EDAT- 2007/03/09 09:00
MHDA- 2007/05/31 09:00
CRDT- 2007/03/09 09:00
PHST- 2007/03/09 09:00 [pubmed]
PHST- 2007/05/31 09:00 [medline]
PHST- 2007/03/09 09:00 [entrez]
AID - 10.1089/cap.2006.0013 [doi]
PST - ppublish
SO  - J Child Adolesc Psychopharmacol. 2007 Feb;17(1):115-20. doi: 
      10.1089/cap.2006.0013.