PMID- 17345039
OWN - NLM
STAT- MEDLINE
DCOM- 20070706
LR  - 20181113
IS  - 0340-5354 (Print)
IS  - 0340-5354 (Linking)
VI  - 254
IP  - 3
DP  - 2007 Mar
TI  - Hyperhomocysteinemia is a risk factor of middle cerebral artery stenosis.
PG  - 364-7
AB  - PURPOSE: Hyperhomocysteinemia (HHcy) is considered to be an independent risk 
      factor for atherosclerosis. We aimed to determine the relation between Hcy and 
      cerebral artery stenosis in a large Chinese population. METHODS: We present data 
      concerning 2,500 residents. Plasma was saved from 1,020 residents who were 
      asymptomatic. Hcy concentration was measured by fluorescence ration biochemical 
      assay kit, and middle cerebral artery (MCA) was assessed by Transcranial Doppler 
      in these subjects. RESULTS: Fifty-six residents with MCA stenosis were included 
      in this study. The remained 964 residents without stenosis were control. Analysis 
      of the data revealed that the plasma concentration of Hcy (18.33+/-5.34 
      micromol/L), age (63.9+/-12.9) and systolic pressure (142.6+/-22.6 mmHg) in the 
      stenotic group were increased (p<0.0001) compared with the control group 
      (Hcy12.95+/-4.57 micromol/L, age 55.8+/-10.9, systolic pressure 126.3+/-20.3 
      mmHg). Based on logistic regression, 5 factors emerged as independent predictors 
      of MCA stenosis: Hcy (OR=1.16, 95%confidence interval 1.14-1.26), male (OR=2.63, 
      95%CI 1.49-4.66), age (OR=1.04, 95%CI 1.01-1.07), hypertension (OR=9.16, 95%CI 
      4.57-18.35), diabetes mellitus (OR=5.90, 95%CI 3.09-11.29). CONCLUSION: 
      Hyperhomocysteinemia might be one of the risk factors for cerebral artery 
      stenosis. It may play a role in atherosclerosis and thrombosis.
FAU - Huang, Hai Wei
AU  - Huang HW
AD  - Department of Neurology, First Affiliated Hospital, Sun Yat-Sen University, 
      Guangzhou, China. hhw2002@sohu.com
FAU - Guo, Ming Hui
AU  - Guo MH
FAU - Lin, Rui Jin
AU  - Lin RJ
FAU - Chen, Ya Li
AU  - Chen YL
FAU - Luo, Qin
AU  - Luo Q
FAU - Zhang, Ying
AU  - Zhang Y
FAU - Wong, Ka Sing
AU  - Wong KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070307
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
RN  - 0 (Triglycerides)
SB  - IM
MH  - Aged
MH  - Blood Pressure/physiology
MH  - Cardiovascular Diseases/diagnostic imaging/epidemiology/*etiology/*pathology
MH  - Chi-Square Distribution
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*complications/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Middle Cerebral Artery/diagnostic imaging/*pathology
MH  - Risk Factors
MH  - Sex Factors
MH  - Triglycerides/metabolism
MH  - Ultrasonography, Doppler, Transcranial/methods
EDAT- 2007/03/09 09:00
MHDA- 2007/07/07 09:00
CRDT- 2007/03/09 09:00
PHST- 2006/01/27 00:00 [received]
PHST- 2006/05/31 00:00 [accepted]
PHST- 2007/03/09 09:00 [pubmed]
PHST- 2007/07/07 09:00 [medline]
PHST- 2007/03/09 09:00 [entrez]
AID - 10.1007/s00415-006-0377-7 [doi]
PST - ppublish
SO  - J Neurol. 2007 Mar;254(3):364-7. doi: 10.1007/s00415-006-0377-7. Epub 2007 Mar 7.