PMID- 17346294
OWN - NLM
STAT- MEDLINE
DCOM- 20071009
LR  - 20181113
IS  - 0905-6157 (Print)
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 18
IP  - 4
DP  - 2007 Jun
TI  - IL13 gene polymorphism association with cord serum immunoglobulin E.
PG  - 288-92
AB  - Interleukin-13 (IL-13) has a pivotal role in the pathway of immunoglobulin E 
      (IgE). Cord serum IgE has been suggested to be associated with allergy later in 
      life, yet less affected by environmental exposures. We investigated the 
      association of the interleukin-13 gene (IL13) polymorphisms on cord serum IgE. In 
      the Isle of Wight birth cohort (UK, 1989-1990), cord serum IgE was measured using 
      the ULTRA EIA kit and was dichotomized at 0.5 kU/l (n = 1358). Five single 
      nucleotide polymorphisms (SNPs: rs1800925 in promoter, rs2066960 in intron 1, 
      rs1295686 in intron 3, rs20541 in exon 4 and rs1295685 in exon 4) in IL13 were 
      genotyped by pyrosequencing method. Linkage analysis using Haploview software 
      revealed that rs1295686, rs20541 and rs1295685 were in strong linkage 
      disequilibrium. Logistic regression and Armitage-Cochran test were used and gene 
      association analysis included 798 children. Confounders were maternal age; 
      maternal smoking, household dog, and household cat during pregnancy; season of 
      birth; sex; position of child in family; and birth weight. SNP rs1295685 was 
      associated with raised cord serum IgE (p = 0.031). This is the first report that 
      shows an association between IL13 polymorphism and cord serum IgE.
FAU - Sadeghnejad, Alireza
AU  - Sadeghnejad A
AD  - Department of Epidemiology and Biostatistics, University of South Carolina, 
      Columbia, South Carolina, USA. asadeghn@wfubmc.edu
FAU - Karmaus, Wilfried
AU  - Karmaus W
FAU - Hasan Arshad, S
AU  - Hasan Arshad S
FAU - Ewart, Susan
AU  - Ewart S
LA  - eng
GR  - R01 AI061471/AI/NIAID NIH HHS/United States
GR  - R01 AI061471-03/AI/NIAID NIH HHS/United States
GR  - AI061471/AI/NIAID NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070307
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Interleukin-13)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fetal Blood/chemistry/*immunology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin E/*blood/genetics
MH  - Infant
MH  - Infant, Newborn
MH  - Interleukin-13/*genetics
MH  - Male
MH  - Maternal Age
MH  - *Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Serum/chemistry/*immunology
PMC - PMC2366045
MID - NIHMS35382
EDAT- 2007/03/10 09:00
MHDA- 2007/10/10 09:00
PMCR- 2008/05/03
CRDT- 2007/03/10 09:00
PHST- 2007/03/10 09:00 [pubmed]
PHST- 2007/10/10 09:00 [medline]
PHST- 2007/03/10 09:00 [entrez]
PHST- 2008/05/03 00:00 [pmc-release]
AID - PAI524 [pii]
AID - 10.1111/j.1399-3038.2006.00524.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2007 Jun;18(4):288-92. doi: 
      10.1111/j.1399-3038.2006.00524.x. Epub 2007 Mar 7.