PMID- 17346300
OWN - NLM
STAT- MEDLINE
DCOM- 20070626
LR  - 20220317
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 18
IP  - 3
DP  - 2007 May
TI  - Phadiatop compared to skin-prick test as a tool for diagnosing atopy in 
      epidemiological studies in schoolchildren.
PG  - 240-4
AB  - The validity of the Phadiatop test as compared to the skin-prick test (SPT) for 
      diagnosing atopy in the epidemiological field has not been studied in 
      schoolchildren. The aim of the present study was to evaluate its validity for 
      classifying schoolchildren 9-12 yr old into atopics and non-atopics. A total of 
      621 children whose parents authorized both a SPT and a blood extraction from all 
      children participating in the phase II of the International Study of Allergies in 
      Children (ISAAC) in Cartagena (Spain) were included in the analysis. A positive 
      SPT was that with at least a wheal having a maximum diameter of 3 mm, once the 
      negative value had been subtracted. Phadiatop was performed according to the 
      manufacturer instructions. Diagnostic tests using SPT as the gold standard were 
      calculated for the whole group of children and also for those with asthma or 
      rhinoconjunctivitis and for children without any of them. The results of the 
      tests were: sensitivity 85.0% (95% CI 82.2-87.8%), specificity 85.5% (95%CI 
      82.7-88.3%), positive predictive value 72.7% (95%CI 69.0-76.1%), negative 
      predictive value 92.7% (95%CI 90.6-94.7%) and accuracy 85.3% (95%CI 82.3-88.0%). 
      The results improved among the symptomatic groups. Phadiatop can be used as a 
      valid alternative to SPT in the epidemiological setting to diagnose atopy.
FAU - Garcia-Marcos, Luis
AU  - Garcia-Marcos L
AD  - Institute of Respiratory Health, University of Murcia, Spain. lgmarcos@um.es
FAU - Sanchez-Solis, Manuel
AU  - Sanchez-Solis M
FAU - Martinez-Torres, Antonia E
AU  - Martinez-Torres AE
FAU - Lucas Moreno, Jose M
AU  - Lucas Moreno JM
FAU - Hernando Sastre, Vicente
AU  - Hernando Sastre V
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070307
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/*diagnosis
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Reproducibility of Results
MH  - Skin Tests
MH  - Spain
EDAT- 2007/03/10 09:00
MHDA- 2007/06/27 09:00
CRDT- 2007/03/10 09:00
PHST- 2007/03/10 09:00 [pubmed]
PHST- 2007/06/27 09:00 [medline]
PHST- 2007/03/10 09:00 [entrez]
AID - PAI508 [pii]
AID - 10.1111/j.1399-3038.2006.00508.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2007 May;18(3):240-4. doi: 
      10.1111/j.1399-3038.2006.00508.x. Epub 2007 Mar 7.