PMID- 17346884
OWN - NLM
STAT- MEDLINE
DCOM- 20070725
LR  - 20240322
IS  - 0304-3940 (Print)
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 417
IP  - 3
DP  - 2007 May 7
TI  - CART peptides increase 5-hydroxytryptamine in the dorsal raphe and nucleus 
      accumbens of freely behaving rats.
PG  - 303-7
AB  - Cocaine and amphetamine-regulated transcript peptides (CART) are implicated in 
      the antidepressant effect. This may involve in 5-hydroxytryptamine (5-HT) in the 
      CNS. The aim of the present studies was to investigate the effect of CART 
      peptides on extracellular 5-HT in the dorsal raphe nucleus (DRN) and nucleus 
      accumbens (NAcc) using a microdialysis approach in freely behaving rats. Reverse 
      infusion of CART61-102 in the DRN produced a concentration (10-100 microM) 
      -dependent increase in 5-HT in the DRN. Similarly, CART62-76 (10-100 microM) 
      infused into the DRN and NAcc elevated 5-HT in the DRN and NAcc, respectively. 
      Thus, CART increases extracellular 5-HT in both the DRN and NAcc. In addition, 
      infusion of CART62-76 (100 microM) in the DRN produced a significant increase in 
      5-HT in the NAcc, implying an existence of CART receptors responsible for the 
      depolarization-dependent release. In summary, the results of the present studies 
      suggest that CART peptides may have an antidepressant effect through increases in 
      extracellular 5-HT.
FAU - Ma, Zhiyuan
AU  - Ma Z
AD  - Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 
      33431, USA.
FAU - Pearson, Elliot
AU  - Pearson E
FAU - Tao, Rui
AU  - Tao R
LA  - eng
GR  - R01 DA014541-02/DA/NIDA NIH HHS/United States
GR  - R01 DA014541-04/DA/NIDA NIH HHS/United States
GR  - R01 DA014541-06/DA/NIDA NIH HHS/United States
GR  - R01 DA014541-05/DA/NIDA NIH HHS/United States
GR  - R01 DA014541-01/DA/NIDA NIH HHS/United States
GR  - R01 DA014541-03/DA/NIDA NIH HHS/United States
GR  - R01 DA014541/DA/NIDA NIH HHS/United States
GR  - DA14541/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070223
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (cocaine- and amphetamine-regulated transcript protein)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects/physiology
MH  - Brain Chemistry/drug effects/*physiology
MH  - Depressive Disorder/drug therapy/metabolism/physiopathology
MH  - Dose-Response Relationship, Drug
MH  - Extracellular Fluid/drug effects/metabolism
MH  - Male
MH  - Microdialysis
MH  - Motor Activity/drug effects/physiology
MH  - Nerve Tissue Proteins/*metabolism/pharmacology
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Raphe Nuclei/drug effects/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Up-Regulation/drug effects/*physiology
PMC - PMC4242193
MID - NIHMS23178
EDAT- 2007/03/10 09:00
MHDA- 2007/07/26 09:00
PMCR- 2014/11/24
CRDT- 2007/03/10 09:00
PHST- 2006/09/21 00:00 [received]
PHST- 2007/02/12 00:00 [revised]
PHST- 2007/02/18 00:00 [accepted]
PHST- 2007/03/10 09:00 [pubmed]
PHST- 2007/07/26 09:00 [medline]
PHST- 2007/03/10 09:00 [entrez]
PHST- 2014/11/24 00:00 [pmc-release]
AID - S0304-3940(07)00232-7 [pii]
AID - 10.1016/j.neulet.2007.02.049 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 May 7;417(3):303-7. doi: 10.1016/j.neulet.2007.02.049. Epub 
      2007 Feb 23.