PMID- 17346891
OWN - NLM
STAT- MEDLINE
DCOM- 20070718
LR  - 20181113
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 146
IP  - 1
DP  - 2007 Apr 25
TI  - Modulation of hippocampal long-term potentiation by slow increases in ethanol 
      concentration.
PG  - 340-9
AB  - To determine how acute ethanol intoxication may alter memory processing, we 
      examined the effects of stepwise increases in ethanol on long-term potentiation 
      (LTP) in rat hippocampal slices. LTP was inhibited by acute administration of 60 
      mM ethanol, but was readily induced if ethanol was increased gradually to 60 mM 
      over 75 min. Administration of 2-amino-5 phosphonovalerate (APV), an 
      N-methyl-D-aspartate receptor (NMDAR) antagonist, during the stepwise increase in 
      ethanol inhibited LTP, suggesting involvement of NMDARs in the development of 
      tolerance. However, APV and nifedipine, an inhibitor of L-type calcium channels, 
      failed to inhibit LTP when administered following the slow increase in ethanol. 
      Ethanol-tolerant LTP was inhibited by thapsigargin, suggesting a major role for 
      intracellular calcium release in this form of plasticity. The unique properties 
      of ethanol-tolerant LTP suggest that memories formed during binge drinking are 
      not acquired by standard synaptic mechanisms and that acute tolerance may involve 
      the induction of novel mechanisms to maintain function.
FAU - Tokuda, K
AU  - Tokuda K
AD  - Department of Psychiatry, Washington University School of Medicine, 660 South 
      Euclid, Box 8134, St. Louis, MO 63110, USA.
FAU - Zorumski, C F
AU  - Zorumski CF
FAU - Izumi, Y
AU  - Izumi Y
LA  - eng
GR  - AA12951/AA/NIAAA NIH HHS/United States
GR  - R01 AG018434/AG/NIA NIH HHS/United States
GR  - P30 DK056341/DK/NIDDK NIH HHS/United States
GR  - R01 AA012951/AA/NIAAA NIH HHS/United States
GR  - P30 DK056341-06/DK/NIDDK NIH HHS/United States
GR  - AG18434/AG/NIA NIH HHS/United States
GR  - DK56341/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070307
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 3K9958V90M (Ethanol)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - I9ZF7L6G2L (Nifedipine)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Calcium Channel Blockers/pharmacology
MH  - Central Nervous System Depressants/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Dose-Response Relationship, Radiation
MH  - Drug Interactions
MH  - Electric Stimulation/methods
MH  - Ethanol/*pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects/radiation effects
MH  - Hippocampus/*drug effects
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/*drug effects/radiation effects
MH  - Male
MH  - Nifedipine/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
PMC - PMC1934937
MID - NIHMS23090
EDAT- 2007/03/10 09:00
MHDA- 2007/07/19 09:00
PMCR- 2008/04/27
CRDT- 2007/03/10 09:00
PHST- 2006/10/03 00:00 [received]
PHST- 2007/01/03 00:00 [revised]
PHST- 2007/01/12 00:00 [accepted]
PHST- 2007/03/10 09:00 [pubmed]
PHST- 2007/07/19 09:00 [medline]
PHST- 2007/03/10 09:00 [entrez]
PHST- 2008/04/27 00:00 [pmc-release]
AID - S0306-4522(07)00072-3 [pii]
AID - 10.1016/j.neuroscience.2007.01.037 [doi]
PST - ppublish
SO  - Neuroscience. 2007 Apr 25;146(1):340-9. doi: 10.1016/j.neuroscience.2007.01.037. 
      Epub 2007 Mar 7.