PMID- 17347135
OWN - NLM
STAT- MEDLINE
DCOM- 20070806
LR  - 20140814
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 97
IP  - 2
DP  - 2007 Jun
TI  - Evaluation of the contact and respiratory sensitization potential of volatile 
      organic compounds generated by simulated indoor air chemistry.
PG  - 355-63
AB  - Up to 60 million people working indoors experience symptoms such as eye, nose and 
      throat irritation, headache, and fatigue. Investigations into these complaints 
      have ascribed the effects to volatile organic compounds (VOCs) emitted from 
      building materials, cleaning formulations, or other consumer products. New 
      compounds can result when the VOCs react with hydroxyl or nitrate radicals or 
      ozone present in indoor environments. Several oxygenated organic compounds, such 
      as glyoxal, methylglyoxal, glycolaldehyde, and diacetyl, have been identified as 
      possible reaction products of indoor environment chemistry. Although research has 
      previously identified diacetyl and glyoxal as sensitizers, additional experiments 
      were conducted in these studies to further classify their sensitization 
      potential. Sensitization potential of these four compounds was assessed using 
      quantitative structure-activity relationship (QSAR) programs. Derek for Windows 
      and National Institute for Occupational Safety and Health logistic regression 
      predicted all compounds to be sensitizers, while TOPKAT 6.2 predicted all 
      compounds except for methylglyoxal. All compounds were tested in a combined 
      irritancy and local lymph node assay (LLNA). All compounds except for glyoxal 
      were found to be irritants and all tested positive in the LLNA with EC3 values 
      ranging from 0.42 to 1.9%. Methylglyoxal significantly increased both the B220(+) 
      and IgE(+)B220(+) cell populations in the draining lymph nodes and total serum 
      IgE levels. The four compounds generated by indoor air chemistry were predicted 
      by QSAR and animal modeling to be sensitizers, with the potential for 
      methylglyoxal to induce IgE. The identification of these compounds as sensitizers 
      may help to explain some of the health effects associated with indoor air 
      complaints.
FAU - Anderson, Stacey E
AU  - Anderson SE
AD  - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. 
      sanderson4@cdc.gov
FAU - Wells, J R
AU  - Wells J
FAU - Fedorowicz, Adam
AU  - Fedorowicz A
FAU - Butterworth, Leon F
AU  - Butterworth LF
FAU - Meade, B J
AU  - Meade B
FAU - Munson, Albert E
AU  - Munson AE
LA  - eng
PT  - Journal Article
DEP - 20070307
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Irritants)
RN  - 0 (Organic Chemicals)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 50NP6JJ975 (Glyoxal)
RN  - 722KLD7415 (Pyruvaldehyde)
RN  - GO1N1ZPR3B (Acetaldehyde)
RN  - K324J5K4HM (Diacetyl)
RN  - W0A0XPU08U (glycolaldehyde)
SB  - IM
CIN - Food Chem Toxicol. 2014 Aug;70:262-3. PMID: 24857816
CIN - Food Chem Toxicol. 2014 Aug;70:260-1. PMID: 24857818
MH  - Acetaldehyde/analogs & derivatives/toxicity
MH  - Air Pollution, Indoor/*adverse effects
MH  - Animals
MH  - Body Weight/drug effects
MH  - Dermatitis, Contact/*pathology
MH  - Diacetyl/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Ear, External/pathology
MH  - Female
MH  - Glyoxal/toxicity
MH  - Immunoglobulin E/blood
MH  - Irritants/toxicity
MH  - Lymph Nodes/drug effects/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Organ Size/drug effects
MH  - Organic Chemicals/administration & dosage/*toxicity
MH  - Phenotype
MH  - Pyruvaldehyde/toxicity
MH  - Quantitative Structure-Activity Relationship
MH  - Respiratory Tract Diseases/*chemically induced/*pathology
EDAT- 2007/03/10 09:00
MHDA- 2007/08/07 09:00
CRDT- 2007/03/10 09:00
PHST- 2007/03/10 09:00 [pubmed]
PHST- 2007/08/07 09:00 [medline]
PHST- 2007/03/10 09:00 [entrez]
AID - kfm043 [pii]
AID - 10.1093/toxsci/kfm043 [doi]
PST - ppublish
SO  - Toxicol Sci. 2007 Jun;97(2):355-63. doi: 10.1093/toxsci/kfm043. Epub 2007 Mar 7.