PMID- 1734719
OWN - NLM
STAT- MEDLINE
DCOM- 19920304
LR  - 20200824
IS  - 0002-9297 (Print)
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Linking)
VI  - 50
IP  - 2
DP  - 1992 Feb
TI  - Fine-scale mapping of the gene responsible for multiple endocrine neoplasia type 
      1 (MEN 1).
PG  - 399-403
AB  - We have constructed a high-resolution genetic linkage map in the vicinity of the 
      gene responsible for multiple endocrine neoplasia type 1 (MEN1). The mutation 
      causing this disease, inherited as an autosomal dominant, predisposes carriers to 
      development of neoplastic tumors in the parathyroid, the endocrine pancreas, and 
      the anterior lobe of the pituitary. The 12 markers on the genetic linkage map 
      reported here span nearly 20 cM, and linkage analysis of MEN1 pedigrees has 
      placed the MEN1 locus within the 8-cM region between D11S480 and D11S546. The 
      markers on this map will be useful for prenatal or presymptomatic diagnosis of 
      individuals in families that segregate a mutant allele of the MEN1 gene.
FAU - Fujimori, M
AU  - Fujimori M
AD  - Department of Biochemistry, Cancer Institute, Tokyo, Japan.
FAU - Wells, S A Jr
AU  - Wells SA Jr
FAU - Nakamura, Y
AU  - Nakamura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
SB  - IM
GS  - MEN1
MH  - Alleles
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 11
MH  - Endocrine Gland Neoplasms/*genetics
MH  - Female
MH  - Genes, Dominant
MH  - Genetic Linkage
MH  - Humans
MH  - Male
MH  - Neoplasms, Multiple Primary/*genetics
MH  - Pancreatic Neoplasms/genetics
MH  - Parathyroid Neoplasms/genetics
MH  - Pituitary Neoplasms/genetics
PMC - PMC1682441
EDAT- 1992/02/11 19:15
MHDA- 2001/03/28 10:01
PMCR- 1992/08/01
CRDT- 1992/02/11 19:15
PHST- 1992/02/11 19:15 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1992/02/11 19:15 [entrez]
PHST- 1992/08/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Hum Genet. 1992 Feb;50(2):399-403.