PMID- 17348821
OWN - NLM
STAT- MEDLINE
DCOM- 20070501
LR  - 20151119
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 27
IP  - 3
DP  - 2007 Mar
TI  - Changes in serum and ascitic monocyte chemotactic protein-1 (MCP-1) and IL-10 
      levels in cirrhotic patients with spontaneous bacterial peritonitis.
PG  - 227-30
AB  - Spontaneous bacterial peritonitis (SBP) is a prototypical infectious disease of 
      cirrhotic patients. It has been suggested that cirrhotic patients' response to 
      infection is less effective because of differences in the inflammatory and immune 
      reactions. This study aimed to investigate the expression of the inflammatory 
      cytokines monocyte chemotactic protein-1 (MCP-1) and interleukin-10 (IL-10) in 
      cirrhotic patients with SBP. The MCP1 and IL-10 levels in the sera and ascitic 
      fluids of cirrhotic patients with (n = 40) or without SBP (n=17) were serially 
      analyzed by ELISA. In the non-SBP group, the mean MCP-1 levels in sera and 
      ascites were 53.0 +/- 45.8 pg/mL and 197.5 +/- 109.5 pg/mL, respectively, and the 
      IL-10 levels were 10.9 +/- 9.5 pg/mL and 77.6 +/- 79.7 pg/mL, respectively. In 
      the SBP group, the mean MCP-1 levels in serum and ascites before treatment were 
      164.7 +/- 126.4 pg/mL and 365.3 +/- 583.0 pg/mL, respectively, and the IL-10 
      levels were 31.4 +/- 44.1 pg/mL and 188.1 +/- 189.5 pg/mL, respectively. The sera 
      MCP-1 and ascites IL-10 levels differed significantly between the two groups. In 
      the SBP group, sera and ascitic MCP-1 and IL-10 levels fell during treatment. The 
      low MCP-1 and IL-10 levels on the seventh day of treatment were found to have a 
      statistically significant relationship to patient survival. MCP-1 and IL-10 
      levels in sera and ascites may be related to the clinical course of SBP.
FAU - Kim, Ja Kyung
AU  - Kim JK
AD  - Department of Internal Medicine, Institute of Gastroenterology, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Chon, Chae Yoon
AU  - Chon CY
FAU - Kim, Jae Hak
AU  - Kim JH
FAU - Kim, Yoon Jae
AU  - Kim YJ
FAU - Cho, Jae Hee
AU  - Cho JH
FAU - Bang, Seung Min
AU  - Bang SM
FAU - Ahn, Sang Hoon
AU  - Ahn SH
FAU - Han, Kwang-Hyub
AU  - Han KH
FAU - Moon, Young Myoung
AU  - Moon YM
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Ascitic Fluid/*metabolism
MH  - Biomarkers/analysis
MH  - Chemokine CCL2/*analysis
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Interleukin-10/*analysis
MH  - Liver Cirrhosis/complications/*metabolism/mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Peritonitis/complications/*metabolism/mortality/therapy
MH  - Predictive Value of Tests
MH  - Retrospective Studies
EDAT- 2007/03/14 09:00
MHDA- 2007/05/02 09:00
CRDT- 2007/03/14 09:00
PHST- 2007/03/14 09:00 [pubmed]
PHST- 2007/05/02 09:00 [medline]
PHST- 2007/03/14 09:00 [entrez]
AID - 10.1089/jir.2006.0055 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2007 Mar;27(3):227-30. doi: 10.1089/jir.2006.0055.