PMID- 17350004
OWN - NLM
STAT- MEDLINE
DCOM- 20070606
LR  - 20081121
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 581
IP  - 7
DP  - 2007 Apr 3
TI  - Overexpression of pitx3 upregulates expression of BDNF and GDNF in SH-SY5Y cells 
      and primary ventral mesencephalic cultures.
PG  - 1357-61
AB  - The transcription factor Pitx3 plays an important role in the development of 
      midbrain to promote the growth and differentiation of dopamine neurons. The 
      present study has demonstrated that overexpression of Pitx3 in SH-SY5Y cells and 
      primary ventral mesencephalic (VM) cultures significantly increased the mRNA 
      levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived 
      neurotrophic factor (GDNF), and remarkably elevated the protein levels of these 
      two neurotrophic factors. Our data provide the first evidence that 
      pitx3-expressing cells are able to upregulate the expression of BDNF and GDNF. 
      Therefore, Pitx3 might be a good target for the treatment of Parkinson's disease.
FAU - Peng, Changgeng
AU  - Peng C
AD  - Institute of Health Sciences, Shanghai Institutes for Biological Sciences, 
      Chinese Academy of Sciences, and Shanghai Jiao Tong University School of 
      Medicine, Shanghai 200025, PR China.
FAU - Fan, Songhua
AU  - Fan S
FAU - Li, Xuping
AU  - Li X
FAU - Fan, Xiaolan
AU  - Fan X
FAU - Ming, Ming
AU  - Ming M
FAU - Sun, Zhe
AU  - Sun Z
FAU - Le, Weidong
AU  - Le W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070302
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 0 (homeobox protein PITX3)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cell Nucleus/chemistry/metabolism
MH  - Gene Expression Regulation
MH  - Glial Cell Line-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Homeodomain Proteins/analysis/genetics/*physiology
MH  - Humans
MH  - Mesencephalon/chemistry/*metabolism
MH  - Mice
MH  - RNA, Messenger/analysis/metabolism
MH  - Rats
MH  - Transcription Factors/analysis/genetics/*physiology
MH  - *Transcriptional Activation
MH  - Transfection
MH  - Transgenes
MH  - Tumor Cells, Cultured
MH  - Up-Regulation
EDAT- 2007/03/14 09:00
MHDA- 2007/06/07 09:00
CRDT- 2007/03/14 09:00
PHST- 2006/12/22 00:00 [received]
PHST- 2007/01/26 00:00 [revised]
PHST- 2007/02/13 00:00 [accepted]
PHST- 2007/03/14 09:00 [pubmed]
PHST- 2007/06/07 09:00 [medline]
PHST- 2007/03/14 09:00 [entrez]
AID - S0014-5793(07)00220-7 [pii]
AID - 10.1016/j.febslet.2007.02.054 [doi]
PST - ppublish
SO  - FEBS Lett. 2007 Apr 3;581(7):1357-61. doi: 10.1016/j.febslet.2007.02.054. Epub 
      2007 Mar 2.