PMID- 17350466
OWN - NLM
STAT- MEDLINE
DCOM- 20070411
LR  - 20070312
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 174
IP  - 1
DP  - 2007 Apr 1
TI  - Novel chromosomal aberrations in a recurrent malignant meningioma.
PG  - 48-53
AB  - The molecular basis of tumorigenesis and tumor progression in meningiomas is not 
      fully understood. Here we present results of conventional cytogenetic, 
      fluorescence in situ hybridization (FISH), and comparative genetic hybridization 
      (CGH) analyses in a patient with recurrent anaplastic meningioma. We found 
      complex aberrant karyotype alterations previously described in anaplastic 
      meningiomas, such as 1p, 14q aberration, and a possibly tetraploid karyotype. 
      Loss of chromosome 22q was detected by conventional cytogenetic analysis. 
      Additional chromosomal aberrations not previously reported included a 
      near-triploid karyotype and alterations such as 4p+, 5p-, 7p+, 8q+, and gain of 
      chromosome 19. FISH with LSI 9p21, CEP9, LSI PML/RARA, and CGH confirmed the 
      karyotype complexity in this case. Our findings of several previously unreported 
      cytogenetic alterations suggest that complex karyotype alterations are a 
      characteristic feature in anaplastic meningiomas. High chromosomal complexity 
      might be associated with a highly aggressive meningioma phenotype.
FAU - Pelz, Antje-Friederike
AU  - Pelz AF
AD  - Department of Human Genetics, Otto-von-Guericke University, Leipziger Strasse 44, 
      D-39120 Magdeburg, Germany.
FAU - Klawunde, Philipp
AU  - Klawunde P
FAU - Skalej, Martin
AU  - Skalej M
FAU - Wieacker, Peter
AU  - Wieacker P
FAU - Kirches, Elmar
AU  - Kirches E
FAU - Schneider, Thomas
AU  - Schneider T
FAU - Mawrin, Christian
AU  - Mawrin C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Carcinoma/*genetics
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human/genetics
MH  - Genome, Human
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Meningeal Neoplasms/*genetics/pathology
MH  - Recurrence
EDAT- 2007/03/14 09:00
MHDA- 2007/04/12 09:00
CRDT- 2007/03/14 09:00
PHST- 2006/10/05 00:00 [received]
PHST- 2006/10/13 00:00 [accepted]
PHST- 2007/03/14 09:00 [pubmed]
PHST- 2007/04/12 09:00 [medline]
PHST- 2007/03/14 09:00 [entrez]
AID - S0165-4608(06)00707-2 [pii]
AID - 10.1016/j.cancergencyto.2006.10.008 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2007 Apr 1;174(1):48-53. doi: 
      10.1016/j.cancergencyto.2006.10.008.