PMID- 17352352
OWN - NLM
STAT- MEDLINE
DCOM- 20070420
LR  - 20220318
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 34
IP  - 1
DP  - 2007 Feb
TI  - Uveitis associated with Primary Angiitis of the Central Nervous System.
PG  - 81-3
AB  - BACKGROUND: In Primary Angiitis of the Central Nervous System (PACNS), disease is 
      typically limited to the brain and spinal cord although other organs may be 
      affected. Uveitis is occasionally seen in systemic vasculitides but is not a 
      recognized manifestation of PACNS. We describe two patients who developed PACNS 
      following the onset of uveitis. CASE DESCRIPTIONS: Case 1--a 47-year-old male 
      suffered multiple TIAs and left pontine stroke shortly after two episodes of 
      diffuse uveitis. A cerbral angiogram demonstrated multiple caliber changes within 
      several intracranial vessels. Cyclophosphamide was added after his stroke 
      occurred during pulse methylprednisolone therapy. Case 2--a 35-year-old male 
      suffered a spinal cord TIA followed by hemispheric and brainstem infarctions two 
      months after an episode of uveitis and Bell's palsy treated with oral prednisone. 
      A cerebral angiogram demonstrated multiple caliber changes within several 
      intracranial vessels. He was successfully treated with oral prednisone and 
      cyclophosphamide. CONCLUSIONS: Uveitis should be considered a recognized feature 
      of PACNS. Combination immunosuppressive therapy with prednisone and 
      cyclophosphamide may be necessary for successful treatment.
FAU - Woolfenden, A R
AU  - Woolfenden AR
AD  - Division of Neurology, Department of Medicine, University of British Columbia, 
      Vancouver, Canada.
FAU - Wade, N K
AU  - Wade NK
FAU - Tang, P
AU  - Tang P
FAU - Chalmers, A
AU  - Chalmers A
FAU - Reid, G
AU  - Reid G
FAU - Teal, P A
AU  - Teal PA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences 
      neurologiques
JID - 0415227
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Steroids)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Adult
MH  - Brain Stem Infarctions/drug therapy/etiology/physiopathology
MH  - Cerebral Angiography
MH  - Cerebral Arteries/diagnostic imaging/*pathology/physiopathology
MH  - Cerebral Infarction/drug therapy/etiology/physiopathology
MH  - Cyclophosphamide/therapeutic use
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Ischemic Attack, Transient/drug therapy/*etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Spinal Cord Ischemia/drug therapy/etiology/physiopathology
MH  - Steroids/therapeutic use
MH  - Stroke/drug therapy/*etiology/physiopathology
MH  - Treatment Outcome
MH  - Uveitis/drug therapy/*etiology/physiopathology
MH  - Vasculitis, Central Nervous System/*complications/drug therapy/physiopathology
EDAT- 2007/03/14 09:00
MHDA- 2007/04/21 09:00
CRDT- 2007/03/14 09:00
PHST- 2007/03/14 09:00 [pubmed]
PHST- 2007/04/21 09:00 [medline]
PHST- 2007/03/14 09:00 [entrez]
AID - 10.1017/s0317167100005837 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2007 Feb;34(1):81-3. doi: 10.1017/s0317167100005837.