PMID- 17353781
OWN - NLM
STAT- MEDLINE
DCOM- 20070420
LR  - 20220330
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 83
IP  - 5
DP  - 2007 Mar 15
TI  - Living donor kidney transplantation: the effects of donor age and gender on 
      short- and long-term outcomes.
PG  - 600-6
AB  - BACKGROUND: The influence of donor age and sex on acute rejection episodes and 
      short- and long-term graft survival in living donor (LD) kidney transplantation 
      has not been well characterized. METHODS: This prospective cohort study includes 
      739 first time LD transplantations with median follow-up time of 55.1 months. 
      Death censored graft survival according to donor age and sex was compared with 
      Kaplan-Meier plots. Cox regression was performed to estimate the association 
      between different risk factors and graft survival and acute rejection episodes. 
      RESULTS: Graft survival was not affected by donor age above 50 years as long as 
      these recipients did not experience an early acute rejection episode. Acute 
      rejection episodes increased in recipients of grafts from donors > or =65 years 
      (P=0.009). Donor age > or =65, recipient age less than 50 years, human leukocyte 
      antigen (HLA)-DR matching, and female donor gender were risk factors for early 
      acute rejection episodes. In multivariate analysis donor age > or =65 years was a 
      risk factor for graft loss in all time periods after transplantation. During the 
      first 5 years after transplantation a steroid resistant rejection episode was an 
      additional risk factor. More than 5 years after transplantation male donor gender 
      was the only additional risk factor for graft loss. CONCLUSION: These results 
      support the continued use of older male and female living donors who meet 
      carefully constructed medical criteria and who are highly motivated to donate. 
      Furthermore, donor age seems to be a more important predictor of graft loss than 
      donor sex.
FAU - Oien, Cecilia Montgomery
AU  - Oien CM
AD  - Faculty of Medicine, University of Oslo, Oslo, Norway. cecilia.oien@stolav
FAU - Reisaeter, Anna Varberg
AU  - Reisaeter AV
FAU - Leivestad, Torbjorn
AU  - Leivestad T
FAU - Dekker, Friedo W
AU  - Dekker FW
FAU - Line, Pal Dag
AU  - Line PD
FAU - Os, Ingrid
AU  - Os I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
MH  - *Age Factors
MH  - Aged
MH  - Blood Group Incompatibility
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/epidemiology
MH  - Graft Survival/physiology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kidney Transplantation/mortality/*physiology
MH  - Living Donors/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Retrospective Studies
MH  - *Sex Characteristics
MH  - Survival Analysis
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2007/03/14 09:00
MHDA- 2007/04/21 09:00
CRDT- 2007/03/14 09:00
PHST- 2007/03/14 09:00 [pubmed]
PHST- 2007/04/21 09:00 [medline]
PHST- 2007/03/14 09:00 [entrez]
AID - 00007890-200703150-00015 [pii]
AID - 10.1097/01.tp.0000255583.34329.dd [doi]
PST - ppublish
SO  - Transplantation. 2007 Mar 15;83(5):600-6. doi: 10.1097/01.tp.0000255583.34329.dd.