PMID- 17353968
OWN - NLM
STAT- MEDLINE
DCOM- 20070509
LR  - 20121115
IS  - 0355-3140 (Print)
IS  - 0355-3140 (Linking)
VI  - 33
IP  - 1
DP  - 2007 Feb
TI  - Occupational asthma and rhinitis in workers from a lasamide production line.
PG  - 74-8
AB  - OBJECTIVES: A wide range of low-molecular-weight agents can cause occupational 
      asthma. The chemical industry is an environment in which numerous hazardous 
      substances are used. Lasamide (2,4-dichloro-5-sulfamoylbenzoic acid) is one of 
      them (along with its precursors). METHODS: Five patients from a lasamide 
      production line with suspected occupational asthma and rhinitis were examined. 
      During the first visit, skin prick tests, total immunoglobulin E (IgE), a 
      nonspecific bronchoprovocation test, and specific bronchoprovocation tests using 
      occupational agents were performed to confirm the diagnosis of allergic diseases. 
      During the follow-up visit (1-3 years after removal from exposure), all of the 
      tests (except the specific bronchoprovocation test) were performed again. 
      RESULTS: At the first hospitalization, the total IgE levels were increased in 
      three patients. In addition, skin prick tests and the nonspecific 
      bronchoprovocation test were positive for three patients. After the specific 
      bronchoprovocation test, serious bronchoconstriction occurred in three patients; 
      symptoms of rhinitis were present in all five patients. Several years after 
      removal from exposure to the occupational agents, normalization (with respect to 
      the parameters followed) was not yet complete for all of the patients. 
      CONCLUSIONS: The process of lasamide production seems to be hazardous and is 
      likely to cause allergic respiratory disease. The prognosis of allergic diseases 
      caused by these products is not very favorable. Allergic symptoms (despite the 
      removal from occupational allergen exposure) persisted even after several years.
FAU - Klusackova, Pavlina
AU  - Klusackova P
AD  - Department of Occupational Medicine, 1st Faculty of Medicine, Charles University 
      and General Teaching Hospital, Prague, Czech Republic. Pavlina.Janu@lf1.cuni.cz
FAU - Lebedova, Jindriska
AU  - Lebedova J
FAU - Pelclova, Daniela
AU  - Pelclova D
FAU - Salandova, Jana
AU  - Salandova J
FAU - Senholdova, Zdenka
AU  - Senholdova Z
FAU - Navratil, Tomas
AU  - Navratil T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Finland
TA  - Scand J Work Environ Health
JT  - Scandinavian journal of work, environment & health
JID - 7511540
RN  - 0 (Benzoates)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - LEG53TF0SN (2,4-dichloro-5-sulfamoylbenzoic acid)
SB  - IM
MH  - Adult
MH  - Asthma/*chemically induced
MH  - Benzoates/*adverse effects
MH  - Bronchial Provocation Tests
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/*chemically induced
MH  - Rhinitis, Allergic, Perennial/*chemically induced
MH  - Skin Tests
EDAT- 2007/03/14 09:00
MHDA- 2007/05/10 09:00
CRDT- 2007/03/14 09:00
PHST- 2007/03/14 09:00 [pubmed]
PHST- 2007/05/10 09:00 [medline]
PHST- 2007/03/14 09:00 [entrez]
AID - 1067 [pii]
PST - ppublish
SO  - Scand J Work Environ Health. 2007 Feb;33(1):74-8.