PMID- 17355242
OWN - NLM
STAT- MEDLINE
DCOM- 20071009
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 18
IP  - 4
DP  - 2007 Jun
TI  - IgE and atopy in perinatally HIV-infected children.
PG  - 298-303
AB  - Elevated serum immunoglobulin E (IgE) and increased prevalence of atopy is 
      reported in patients infected with human immunodeficiency virus (HIV). The 
      elevated serum IgE may be attributed to polyclonal stimulation of B cells or IgE 
      production against allergens, viruses, fungi and bacteria. This study 
      investigates the prevalence of atopy in perinatally HIV-infected children, and 
      the relationships between serum IgE (and other serum immunoglobulins) with atopy, 
      CD4+ cell count and HIV-disease stage. Serum immunoglobulin levels, epicutaneous 
      skin test for common aeroallergens, clinical Centers for Disease Control and 
      Prevention (CDC) classification, CD4+ cell counts and allergy history were 
      extracted from the charts of perinatally HIV-infected children on highly active 
      antiretroviral therapy. The prevalence of atopy (52%) and the pattern of 
      aeroallergen sensitivity were comparable with the US pediatric population. Serum 
      IgE levels did not correlate with clinical disease stage. However, in non-atopic 
      patients, serum IgE levels increased with disease progression (p = 0.02). There 
      was an inverse relationship between the prevalence of elevated serum IgE levels 
      and atopy with progression of disease (p = 0.019). Serum IgE did not correlate 
      with atopy, CD4+ cell count, or duration of HIV infection or levels of serum 
      immunoglobulins. This is the first study to show no increased prevalence of atopy 
      in perinatally HIV-infected children compared with the general population. In 
      advanced stages of HIV, elevated serum IgE may be specific for antigens other 
      than those known as allergens.
FAU - Bowser, Corinna S
AU  - Bowser CS
AD  - Division of Allergy and Immunology, Department of Pediatrics and Medicine, SUNY 
      Downstate Medical Center, Brooklyn, NY 11203, USA.
FAU - Kaye, Jean
AU  - Kaye J
FAU - Joks, Rauno O
AU  - Joks RO
FAU - Charlot, Cascy-Arnoux
AU  - Charlot CA
FAU - Moallem, H Jack
AU  - Moallem HJ
LA  - eng
PT  - Journal Article
DEP - 20070307
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Flow Cytometry
MH  - HIV Infections/complications/*congenital/*immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/complications/*epidemiology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Prevalence
MH  - Skin Tests
EDAT- 2007/03/16 09:00
MHDA- 2007/10/10 09:00
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2007/10/10 09:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
AID - PAI522 [pii]
AID - 10.1111/j.1399-3038.2006.00522.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2007 Jun;18(4):298-303. doi: 
      10.1111/j.1399-3038.2006.00522.x. Epub 2007 Mar 7.