PMID- 17356131
OWN - NLM
STAT- MEDLINE
DCOM- 20070927
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 110
IP  - 1
DP  - 2007 Jul 1
TI  - Induction of antigen-specific regulatory T lymphocytes by human dendritic cells 
      expressing the glucocorticoid-induced leucine zipper.
PG  - 211-9
AB  - Dendritic cells (DCs) determine whether antigen presentation leads to immune 
      activation or to tolerance. Tolerance-inducing DCs (also called regulatory DCs) 
      act partly by generating regulatory T lymphocytes (Tregs). The mechanism used by 
      DCs to switch toward regulatory DCs during their differentiation is unclear. We 
      show here that human DCs treated in vitro with glucocorticoids produce the 
      glucocorticoid-induced leucine zipper (GILZ). Antigen presentation by 
      GILZ-expressing DCs generates CD25(high)FOXP3(+)CTLA-4/CD152(+) and 
      interleukin-10-producing Tregs inhibiting the response of CD4(+) and CD8(+) T 
      lymphocytes. This inhibition is specific to the antigen presented, and only 
      proliferating CD4(+) T lymphocytes express the Treg markers. Interleukin-10 is 
      required for Treg induction by GILZ-expressing DCs. It is also needed for the 
      suppressive function of Tregs. Antigen-presenting cells from patients treated 
      with glucocorticoids generate interleukin-10-secreting Tregs ex vivo. These 
      antigen-presenting cells produce GILZ, which is needed for Treg induction. 
      Therefore, GILZ is critical for commitment of DCs to differentiate into 
      regulatory DCs and to the generation of antigen-specific Tregs. This mechanism 
      may contribute to the therapeutic effects of glucocorticoids.
FAU - Hamdi, Haifa
AU  - Hamdi H
AD  - Institut National de la Sante et de la Recherche Medicale, Clamart, France.
FAU - Godot, Veronique
AU  - Godot V
FAU - Maillot, Marie-Christine
AU  - Maillot MC
FAU - Prejean, Maria Victoria
AU  - Prejean MV
FAU - Cohen, Nicolas
AU  - Cohen N
FAU - Krzysiek, Roman
AU  - Krzysiek R
FAU - Lemoine, Francois M
AU  - Lemoine FM
FAU - Zou, Weiping
AU  - Zou W
FAU - Emilie, Dominique
AU  - Emilie D
LA  - eng
GR  - R01 HL074399/HL/NHLBI NIH HHS/United States
GR  - R01 HL079584/HL/NHLBI NIH HHS/United States
GR  - R01 HL080499/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070313
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Glucocorticoids)
RN  - 0 (TSC22D3 protein, human)
RN  - 0 (Transcription Factors)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Antigen Presentation/*immunology
MH  - Cell Communication/immunology
MH  - Cell Differentiation/drug effects
MH  - Dendritic Cells/cytology/*immunology
MH  - Glucocorticoids/*pharmacology
MH  - Humans
MH  - Immunophenotyping
MH  - Interleukin-10/immunology
MH  - *T-Cell Antigen Receptor Specificity
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Transcription Factors/*biosynthesis/drug effects
PMC - PMC2077304
COIS- Conflict-of-interest disclosure: The author declares no competing financial 
      interests. ■
EDAT- 2007/03/16 09:00
MHDA- 2007/09/28 09:00
PMCR- 2008/11/15
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2007/09/28 09:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
PHST- 2008/11/15 00:00 [pmc-release]
AID - S0006-4971(20)41327-8 [pii]
AID - 2007/107896 [pii]
AID - 10.1182/blood-2006-10-052506 [doi]
PST - ppublish
SO  - Blood. 2007 Jul 1;110(1):211-9. doi: 10.1182/blood-2006-10-052506. Epub 2007 Mar 
      13.