PMID- 17357204
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20070314
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 10
IP  - 4
DP  - 2005 Oct-Dec
TI  - Cancer and venous thromboembolism.
PG  - 483-9
AB  - Clinical examples of coagulation abnormalities may occur from single or multiple 
      abnormailties and include both inherited and acquired defects. Risk factors that 
      further increase clotting include obesity, recent surgery, pregnancy and cancer. 
      Venous thrombosis is a common complication in patients with malignant diseases. 
      The estimates of the prevalence of cancer among patients with venous thrombosis 
      vary from 3 to 18%. Since cancer is a common disorder in the aging population, it 
      may be responsible for a considerable proportion of all cases of thrombosis. The 
      pathogenic mechanisms of thrombosis in the cancer patient involve a complex 
      interaction between the tumor cell, the patient, and the hemostatic system. These 
      include activation of the coagulation system, platelet activation, endothelial 
      damage, indwelling venous access devices, direct effects of chemotherapy/hormonal 
      therapy, and host inflammatory responses. Furthermore, local peritumoral 
      activation of coagulation may have important effects on the biology of cancer. In 
      recent years there have been many new developments in understanding basic 
      mechanisms and optimizing clinical care of thrombosis in cancer patients. 
      Subcutaneous low-molecular weight heparin LMWH) has replaced intravenous 
      unfractionated heparin (UFH) for the initial treatment of thrombosis. In the 
      search for new agents matching the "ideal" anticoagulant profile, a number of 
      different steps in the coagulation cascade have been targeted, including direct 
      thrombin inhibition, and inhibition of factor Xa, factor IXa, the factor 
      VIIa-tissue factor complex and the factor Va-factor VIIIa complex. Such agents 
      could potentially improve thrombosis magement in cancer patients.
FAU - Grudeva-Popova, J
AU  - Grudeva-Popova J
AD  - Department of Hematology, University Hospital - Plovdid, Bulgaria.
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
EDAT- 2007/03/16 09:00
MHDA- 2007/03/16 09:01
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2007/03/16 09:01 [medline]
PHST- 2007/03/16 09:00 [entrez]
PST - ppublish
SO  - J BUON. 2005 Oct-Dec;10(4):483-9.