PMID- 17357299
OWN - NLM
STAT- MEDLINE
DCOM- 20070705
LR  - 20080515
IS  - 1896-1126 (Print)
IS  - 1896-1126 (Linking)
VI  - 51
DP  - 2006
TI  - Myeloid and lymphoid dendritic cells and cytotoxic T lymphocytes in peripheral 
      blood of non-small cell lung cancer patient--a pilot study.
PG  - 160-3
AB  - PURPOSE: Dendritic cells (DCs) and cytotoxic T lymphocytes (CTLs) are the first 
      protecting barrier against different pathogens (viruses, bacteria and neoplasms 
      cells). Immature myeloid- and lymphoid dendritic cells possess ability to 
      phagocytose and present antigens to lymphocytes. They have also ability to 
      produce IL-12, which is also known as natural killer cell stimulatory factor or 
      cytototoxic lymphocyte maturation factor. The aim of the study was to demonstrate 
      the relationship between percentage of immature dendritic cells and percentage of 
      CTLs subtypes in peripheral blood of non-small cell lung cancer (NSCLC). MATERIAL 
      AND METHODS: The study population consisted of 10 patients suffered from NSCLC 
      (the mean age: 61.8 +/- 10.55). The monoclonal antibodies and three-color flow 
      cytometry technique was applied to determine the cells phenotype in peripheral 
      blood. RESULTS: Significant negative correlation (R = -0.693, p < 0.05) between 
      percentage of lymphoid DCs and percentage of CTLs was shown. The myeloid to 
      lymphoid DCs ratio significantly positively (R = +0.638, p < 0.05) correlated 
      with the percentage of CTLs. The significant negative correlation between the 
      percentage of myeloid DCs and the percentage of CTLs-IL-12R-positive cells, as 
      well as expression of this receptor were also ascertained (R = -0.68, p < 0.05 
      and R = -0.757, p < 0.01, respectively). CONCLUSIONS: In presented pilot study we 
      demonstrated clearly relationship between the percentage of immature DCs and the 
      percentage and the phenotype of CTLs in peripheral blood of lung cancer patients.
FAU - Krawczyk, P
AU  - Krawczyk P
AD  - Department of Pneumonology, Oncology and Allergology, Medical University of 
      Lublin, ul. Jaczewskiego 8, 20-950 Lublin, Poland. pulm.dept@am.lublin.pl
FAU - Wojas, K
AU  - Wojas K
FAU - Milanowski, P
AU  - Milanowski P
FAU - Rolinski, J
AU  - Rolinski J
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Adv Med Sci
JT  - Advances in medical sciences
JID - 101276222
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*blood/immunology/pathology
MH  - Dendritic Cells/*cytology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Interleukin-12/metabolism
MH  - Lung Neoplasms/*blood/immunology/pathology
MH  - Lymphocytes/cytology/immunology/metabolism
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - T-Lymphocytes, Cytotoxic/*cytology
EDAT- 2007/03/16 09:00
MHDA- 2007/07/06 09:00
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2007/07/06 09:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
PST - ppublish
SO  - Adv Med Sci. 2006;51:160-3.