PMID- 17357480
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20191110
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 26
IP  - 6
DP  - 2006
TI  - Effects of impaired glucose metabolism on heart rate variability and blood 
      pressure variability in essential hypertension patients.
PG  - 654-6
AB  - To investigate the effects of impaired glucose metabolism (IGM) on cardiovascular 
      autonomic nervous systems in essential hypertensive (EH) patients by comparing 
      heart rate variability (HRV) and blood pressure variability (BPV) in EH patients 
      with or without type 2 diabetes mellitus (T2DM). Simultaneous 24-h recordings of 
      ambulatory ECG and blood pressure monitoring were performed in 36 male old 
      patients with simple EH and 33 male old patients with EH combined with T2DM. HRV 
      analysis included time domain parameters such as SDNN, SDANN, SDNNi, rMSSD and 
      pNN50, and total spectral power (TP) of HRV, which mainly consists of VLF, LF and 
      HF component along with LF/HF ratio, was also obtained. The value of ambulatory 
      blood pressure was represented as the mean blood pressure (mean systolic/mSBP, 
      diastolic/mDBP and pulse pressure/mPP) during different periods (24 h/24 h, day 
      time/d and night time/n). Standard deviation (SD) as well as coefficient of 
      variance (CV) of blood pressure during each above-mentioned period were obtained 
      to reflect the long-term BPV. Our result showed that SDNN, SDNNi, SDANN, rMSSD, 
      PNN50, TP and HF of HRV in cases of EH with T2DM were all significantly lower 
      than those in simple EH subjects (P<0.05). No significant differences in VLF or 
      LF was found between the two groups (P>0.05), while LF/HF ratio was significantly 
      higher in EH with T2DM patients than in simple EH subjects (P<0.01). Moreover, 
      dmSBP, 24 h-mPP and dmPP were all significantly higher in EH with T2DM patients 
      than in simple EH subjects (P<0.05), while nmSBP, 24 h-mSBP, 24 h-mDBP, dmDBP, 
      nmDBP or nmPP showed no significant difference between this two groups of 
      patients (P>0.05). And dSBPSD, dSBPCV and 24 h-SBPSD were all significantly 
      higher in EH with T2DM patients than in simple EH subjects (P<0.05), while the 
      other BPV indexes showed no significant difference between this two groups 
      (P>0.05). It is concluded that the cardiovascular autonomic nervous systems in EH 
      patients was further impaired by T2DM, displaying lowering of HRV and enlargement 
      of BPV, which in turn induced abnormal structural and functional changes of 
      cardiovascular systems. Therefore, improving cardiovascular autonomic nervous 
      systems might reduce the occurrence of cardiovascular complications in the EH 
      patients with IGM.
FAU - Wang, Gang
AU  - Wang G
AD  - Department of Gerontology,General Hospital of Guangzhou Military Command, 
      Guangzhou 510010, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Pressure/*physiology
MH  - Diabetes Mellitus, Type 2/metabolism/physiopathology
MH  - Glucose/*metabolism
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Hypertension/metabolism/*physiopathology
MH  - Male
MH  - Middle Aged
EDAT- 2007/03/16 09:00
MHDA- 2014/01/24 06:00
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
AID - 10.1007/s11596-006-0606-4 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2006;26(6):654-6. doi: 
      10.1007/s11596-006-0606-4.