PMID- 17357513
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20140625
VI  - 20
IP  - 24
DP  - 2006 Dec
TI  - [The expression of tumor necrosis factor related apoptosis induce ligand in human 
      laryngeal squamous cell carcinoma].
PG  - 1105-8
AB  - OBJECTIVE: To study the expression of tumor necrosis factor related apoptosis 
      induce ligand (TRAIL) receptors (DR4, DR5, DcR1, DcR2) in human laryngeal 
      squamous cell carcinoma (LSCC). METHOD: The expression and distribution of DR4, 
      DR5, DcR1, DcR2 were detected by immunohistochemical method in 68 patients of 
      LSCC and 40 laryngeal normal tissues (LNT). RESULT: All of TRAIL receptors was 
      observed in both tissues of LSCC and LNT. It was found that DR4, DR5 were 
      overexpressed in the two tissues, indicating that there were no significant 
      difference between the expressions of DR4 and DR5 in two tissues (P >0.05). DcR1 
      , DcR2 were over-expressed in LNT,were low expressed in LSCC (P <0. 05). Level of 
      the TRAIL receptors DR5, DcR2 related with the degree of LSCC histological 
      differentiation (P <0. 05). All receptors were not related with different 
      clinical stage (P >0.05). CONCLUSION: TRAIL receptors expression is generally 
      expressed in human LSCC and LNT. The expression level of TRAIL receptors is 
      various, which may explain the anti-cancer effect of TRAIL. The TRAIL receptor 
      DcR1, DcR2 may play an important role in the apoptosis regulation of LSCC.
FAU - Yao, Hongchao
AU  - Yao H
AD  - Department of Otolaryngology, the Second Affiliated Hospital of China Medical 
      University, Shenyang, 110001, China.
FAU - Ji, Wenyue
AU  - Ji W
FAU - Guan, Chao
AU  - Guan C
FAU - Liu, Bin
AU  - Liu B
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Receptors, TNF-Related Apoptosis-Inducing Ligand)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Case-Control Studies
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Neoplasm Staging
MH  - Receptors, TNF-Related Apoptosis-Inducing Ligand/*metabolism
EDAT- 2007/03/16 09:00
MHDA- 2011/04/08 06:00
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Dec;20(24):1105-8.