PMID- 17357514
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20140625
VI  - 20
IP  - 24
DP  - 2006 Dec
TI  - [Expression and clinical significance of matrix metalloproteinase-2 in laryngeal 
      squamous cell carcinoma].
PG  - 1109-10
AB  - OBJECTIVE: To investigate the relationship between the expression of matrix 
      metalloproteinase-2 (MMP-2) and clinical significance of laryngeal squamous cell 
      carcinomas (LSCC). METHOD: Expression of the MMP-2 was detected by 
      immunohistochemical method in 63 cases of LSCC, 20 cases of adjacent safety 
      margin (ASM) and 18 cases of vocal cord polyp (VCP). RESULT: The positive 
      percentage of active MMP-2 expression were 66.7%, 33. 3% and 15. 0%, in LSCC,VCP 
      and ASM respectively. Significant differences ( P <0. 05) were observed among the 
      three group; there was a significant differences in the expression of MMP-2 among 
      the different pathologic degree I , II , III; no significant difference in the 
      expression of MMP-2 between lymphoid metastasis and no lymphoid metastasis ( P 
      >0. 05); Age and clinical stage did not change the expressions of the MMP-2 
      expression ( P <0. 05). CONCLUSION: MMP-2 probably plays an important role in the 
      carcinogenesis and progression of LSCC. But it may be an unnecessary factor in 
      the metastases of LSCC.
FAU - Wang, Xiaoqian
AU  - Wang X
AD  - Department of Otorhinolaryngology, the People' s Hospital of Guangdong Province, 
      Guangzhou, 510630, China.
FAU - Shan, Yanchun
AU  - Shan Y
FAU - Wang, Jiqun
AU  - Wang J
FAU - Luo, Sijin
AU  - Luo S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Matrix Metalloproteinase 2/*metabolism
MH  - Middle Aged
MH  - Neoplasm Staging
EDAT- 2007/03/16 09:00
MHDA- 2011/04/08 06:00
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Dec;20(24):1109-10.