PMID- 17357515
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20181201
VI  - 20
IP  - 24
DP  - 2006 Dec
TI  - [The clinical significance of molecular findings in surgically resected margins 
      of the primary tumor laryngeal carcinoma].
PG  - 1111-3
AB  - OBJECTIVE: To study the relationship at molecular level between the resection 
      range of laryngeal squamous cell carcinoma (LSCC) and prognosis. METHOD: 
      Immunohistochemistry method was used to detected the expression of EGFR, 
      p27,Bcl-2 and p53 in surgically resected margins of the 23 patients with LSCC. 
      The relationship between the genes and tumour recurrence were observed by the 
      follow-up. RESULT: Seven margin tissues of tumors had detectable Bcl-2 
      expression; eleven margin tissues overexpressed p27; and three expressed p53 and 
      EGFR. Four of the 23 patients have had tumor recurrence and their expression of 
      p27, p53 and EGFR were negative; the expression of Bcl-2 was positive in two 
      patients of the four recurrences patients. The rest were alive unrelated causes 
      without clinical (good outcome). Expression of neither EGFR nor p53 was 
      associated with recurrence. Only p27 was significantly associated with outcome 
      and disease-free survival. CONCLUSION: These data indicate that assessing 
      expression of multiple genes with immunohistochemistry in margin tissues is 
      likely to be useful for surgically treated advanced laryngeal carcinoma. The 
      expression of the p27 is more important.
FAU - Jin, Xiaojie
AU  - Jin X
AD  - Department of Otolaryngology-Head and Neck Surgery, Renji Hospital, Shanghai 
      Jiaotong University, Shanghai, 200001, China.
FAU - Qian, Minfei
AU  - Qian M
FAU - Xu, Yanping
AU  - Xu Y
FAU - Zheng, Luying
AU  - Zheng L
FAU - Wang, Jiadong
AU  - Wang J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/metabolism/*pathology/surgery
MH  - Cyclin-Dependent Kinase Inhibitor p27/metabolism
MH  - ErbB Receptors/metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/metabolism/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-bcl-2/metabolism
MH  - Tumor Suppressor Protein p53/metabolism
EDAT- 2007/03/16 09:00
MHDA- 2011/04/08 06:00
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Dec;20(24):1111-3.