PMID- 17357516
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20181201
VI  - 20
IP  - 24
DP  - 2006 Dec
TI  - [Expression and clinical significance of survivin gene and PTEN gene in laryngeal 
      squamous cell carcinomas].
PG  - 1113-5
AB  - OBJECTIVE: To investigate the expression and clinical significance of 
      anti-apoptosis gene Survivin and tumor suppressor gene PTEN in laryngeal squamous 
      cell carcinomas (LSCC) METHOD: The expression of Survivin and PTEN protein were 
      detected by immunohistochemistry Envision method in 71 specimens of LSCC, and 10 
      specimens of vocal cord polyp as control. RESULT: No Survivin was detected in 
      polyp of vocal cord. However, it was detected in 53 of 71 (74. 6%) specimens from 
      the patients with LSCC. The Survivin expression was unrelated to the age and sex 
      of patients or the size of tumors ( P >0.05) ,but related to the tumor site, 
      clinical stage, histological grade, lymphatic metastasis and tumor prognosis ( P 
      <0. 05). PTEN had the expression in all specimens of vocal cord polyp. However, 
      it was detected in 33 of 71 (46. 5%) specimens of laryngeal carcinoma. The PTEN 
      expression was unrelated to the clinical data including age, gender, tumor size 
      and site ( P >0. 05), but related to the clinical stage, pathological grade, 
      lymph node metastasis and prognosis ( P <0. 05). There was a negative correlation 
      between Survivin expression and PTEN expression ( P <0. 05). CONCLUSION: The 
      abnormal expression of Survivin and PTEN gene may be related to carcinogenesis, 
      tumor progress and prognosis. The Survivin and PTEN gene may act as markers 
      predicting biological behavior of LSCC. The coexpression of Survivin and PTEN 
      gene have the synergism in carcinogenesis and tumor progress of LSCC.
FAU - Zhu, Li
AU  - Zhu L
AD  - Department of Pathology, Affiliated Eye Ear Nose Throat Hospital, Fudan 
      University, Shanghai, 200031, China.
FAU - Wang, Shuyi
AU  - Wang S
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Survivin)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Microtubule-Associated Proteins/*metabolism
MH  - Middle Aged
MH  - PTEN Phosphohydrolase/*metabolism
MH  - Prognosis
MH  - Survivin
EDAT- 2007/03/16 09:00
MHDA- 2011/04/08 06:00
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Dec;20(24):1113-5.