PMID- 17359244
OWN - NLM
STAT- MEDLINE
DCOM- 20071214
LR  - 20091103
IS  - 1462-8902 (Print)
IS  - 1462-8902 (Linking)
VI  - 9
IP  - 5
DP  - 2007 Sep
TI  - Plasma adipocyte and epidermal fatty acid binding protein is reduced after weight 
      loss in obesity.
PG  - 761-3
AB  - AIM: Plasma adipocyte fatty acid binding protein (A-FABP) and epidermal fatty 
      acid binding protein (E-FABP) concentrations have been linked to obesity and the 
      metabolic syndrome. In this study, we investigated whether plasma A-FABP and 
      E-FABP concentrations are altered by weight loss in obese patients. METHODS: In a 
      prospective study, fasting plasma A-FABP and E-FABP concentrations were measured 
      before and 6 months after gastric banding in 33 morbidly obese patients, with a 
      body mass index (BMI) of 46 +/- 5 kg/m(2). Eleven healthy subjects with a BMI < 
      25 kg/m(2) served as controls. RESULTS: A-FABP and E-FABP plasma concentrations 
      were higher in obese subjects (36.7 +/- 6.7 and 3.7 +/- 0.7 ng/ml, respectively) 
      than in controls (18.1 +/- 0.6 and 2.6 +/- 0.5, respectively, p < 0.01). Gastric 
      banding reduced BMI to 40 +/- 5 kg/m(2), A-FABP to 32.6 +/- 5.4 ng/ml and E-FABP 
      to 1.9 +/- 0.7 ng/ml (all p < 0.05) after 6 months. Insulin sensitivity as 
      estimated by the Homeostasis Model Assessment insulin resistance index was 
      unchanged. A-FABP concentrations were significantly associated with BMI before 
      and 6 months after surgery (p < 0.05, r = 0.42 and r = 0.37 respectively). 
      CONCLUSIONS: Elevated plasma A-FABP and E-FABP concentrations in morbidly obese 
      subjects are reduced after gastric banding-induced weight loss. This suggests 
      that FABP may be associated with improvement of metabolic conditions over time.
FAU - Haider, D G
AU  - Haider DG
FAU - Schindler, K
AU  - Schindler K
FAU - Bohdjalian, A
AU  - Bohdjalian A
FAU - Prager, G
AU  - Prager G
FAU - Luger, A
AU  - Luger A
FAU - Wolzt, M
AU  - Wolzt M
FAU - Ludvik, B
AU  - Ludvik B
LA  - eng
PT  - Letter
DEP - 20070313
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
RN  - 0 (FABP5 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
SB  - IM
MH  - Adipocytes/*metabolism
MH  - Adult
MH  - Body Mass Index
MH  - Fatty Acid-Binding Proteins/blood/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Obesity/complications/*metabolism
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Weight Loss
EDAT- 2007/03/16 09:00
MHDA- 2007/12/15 09:00
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2007/12/15 09:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
AID - DOM717 [pii]
AID - 10.1111/j.1463-1326.2007.00717.x [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2007 Sep;9(5):761-3. doi: 10.1111/j.1463-1326.2007.00717.x. 
      Epub 2007 Mar 13.