PMID- 17360322
OWN - NLM
STAT- MEDLINE
DCOM- 20070430
LR  - 20181113
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 104
IP  - 12
DP  - 2007 Mar 20
TI  - Human herpesvirus 6A accelerates AIDS progression in macaques.
PG  - 5067-72
AB  - Although HIV is the necessary and sufficient causative agent of AIDS, genetic and 
      environmental factors markedly influence the pace of disease progression. 
      Clinical and experimental evidence suggests that human herpesvirus 6A (HHV-6A), a 
      cytopathic T-lymphotropic DNA virus, fosters the progression to AIDS in synergy 
      with HIV-1. In this study, we investigated the effect of coinfection with HHV-6A 
      on the progression of simian immunodeficiency virus (SIV) disease in pig-tailed 
      macaques (Macaca nemestrina). Inoculation of HHV-6A resulted in a rapid 
      appearance of plasma viremia associated with transient clinical manifestations 
      and followed by antibody seroconversion, indicating that this primate species is 
      susceptible to HHV-6A infection. Whereas animals infected with HHV-6A alone did 
      not show any long-term clinical and immunological sequelae, a progressive loss of 
      CD4(+) T cells was observed in all of the macaques inoculated with SIV. However, 
      progression to full-blown AIDS was dramatically accelerated by coinfection with 
      HHV-6A. Rapid disease development in dually infected animals was heralded by an 
      early depletion of both CD4(+) and CD8(+) T cells. These results provide in vivo 
      evidence that HHV-6A may act as a promoting factor in AIDS progression.
FAU - Lusso, Paolo
AU  - Lusso P
AD  - Unit of Human Virology, San Raffaele Scientific Institute, 20132 Milan, Italy. 
      paolo.lusso@hsr.it
FAU - Crowley, Richard W
AU  - Crowley RW
FAU - Malnati, Mauro S
AU  - Malnati MS
FAU - Di Serio, Clelia
AU  - Di Serio C
FAU - Ponzoni, Maurilio
AU  - Ponzoni M
FAU - Biancotto, Angelique
AU  - Biancotto A
FAU - Markham, Phillip D
AU  - Markham PD
FAU - Gallo, Robert C
AU  - Gallo RC
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070314
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/chemically induced/*pathology/*virology
MH  - Animals
MH  - Disease Progression
MH  - Gene Expression Regulation, Viral
MH  - Herpesvirus 6, Human/*physiology
MH  - Humans
MH  - Lymph Nodes/virology
MH  - Macaca/*virology
MH  - RNA, Messenger/genetics/metabolism
MH  - RNA, Viral/genetics/metabolism
MH  - Simian Immunodeficiency Virus/physiology
MH  - Virus Replication/physiology
PMC - PMC1829265
COIS- The authors declare no conflict of interest.
EDAT- 2007/03/16 09:00
MHDA- 2007/05/01 09:00
PMCR- 2007/09/20
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2007/05/01 09:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
PHST- 2007/09/20 00:00 [pmc-release]
AID - 0700929104 [pii]
AID - 5653 [pii]
AID - 10.1073/pnas.0700929104 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5067-72. doi: 
      10.1073/pnas.0700929104. Epub 2007 Mar 14.