PMID- 17360672
OWN - NLM
STAT- MEDLINE
DCOM- 20070613
LR  - 20240413
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 104
IP  - 9
DP  - 2007 Feb 27
TI  - Selective retention of herpes simplex virus-specific T cells in latently infected 
      human trigeminal ganglia.
PG  - 3496-501
AB  - Primary infection with herpes simplex virus 1 (HSV-1) and varicella zoster virus 
      (VZV) results in lifelong latent infections of neurons in sensory ganglia such as 
      the trigeminal ganglia (TG). It has been postulated that T cells retained in TG 
      inhibit reactivation of latent virus. The acquisition of TG specimens of 
      individuals within hours after death offered the unique opportunity to 
      characterize the phenotype and specificity of TG-resident T cells in humans. High 
      numbers of activated CD8(+) T cells expressing a late effector memory phenotype 
      were found to reside in latently infected TG. The T cell infiltrate was 
      oligoclonal, and T cells selectively clustered around HSV-1 but not VZV latently 
      infected neurons. Neuronal damage was not observed despite granzyme B expression 
      by the neuron-interacting CD8(+) T cells. The TG-resident T cells, mainly CD8(+) 
      T cells, were directed against HSV-1 and not to VZV, despite neuronal expression 
      of VZV proteins. The results implicate that herpesvirus latency in human TG is 
      associated with a local, persistent T cell response, comprising activated late 
      effector memory CD8(+) T cells that appear to control HSV-1 latency by 
      noncytolytic pathways. In contrast, T cells do not seem to be directly involved 
      in controlling VZV latency in human TG.
FAU - Verjans, Georges M G M
AU  - Verjans GM
AD  - Department of Virology, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, 
      Rotterdam, The Netherlands. g.verjans@erasmusmc.nl
FAU - Hintzen, Rogier Q
AU  - Hintzen RQ
FAU - van Dun, Jessica M
AU  - van Dun JM
FAU - Poot, Angelique
AU  - Poot A
FAU - Milikan, Johannes C
AU  - Milikan JC
FAU - Laman, Jon D
AU  - Laman JD
FAU - Langerak, Anton W
AU  - Langerak AW
FAU - Kinchington, Paul R
AU  - Kinchington PR
FAU - Osterhaus, Albert D M E
AU  - Osterhaus AD
LA  - eng
GR  - R01 EY009397/EY/NEI NIH HHS/United States
GR  - EY08098/EY/NEI NIH HHS/United States
GR  - EY09397/EY/NEI NIH HHS/United States
GR  - R01 EY015291/EY/NEI NIH HHS/United States
GR  - EY15291/EY/NEI NIH HHS/United States
GR  - P30 EY008098/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070220
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antibodies, Monoclonal)
RN  - EC 3.4.21.- (Granzymes)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - CD8-Positive T-Lymphocytes/*immunology/metabolism
MH  - Granzymes/metabolism
MH  - Herpesviridae Infections/immunology/*virology
MH  - *Herpesvirus 1, Human
MH  - *Herpesvirus 3, Human
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Trigeminal Ganglion/cytology/*virology
MH  - Virus Latency/*immunology
PMC - PMC1805572
COIS- The authors declare no conflict of interest.
EDAT- 2007/03/16 09:00
MHDA- 2007/06/15 09:00
PMCR- 2007/08/27
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
PHST- 2007/08/27 00:00 [pmc-release]
AID - 0610847104 [pii]
AID - 5453 [pii]
AID - 10.1073/pnas.0610847104 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3496-501. doi: 
      10.1073/pnas.0610847104. Epub 2007 Feb 20.