PMID- 17360918
OWN - NLM
STAT- MEDLINE
DCOM- 20070405
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 27
IP  - 11
DP  - 2007 Mar 14
TI  - Recognition memory for objects, place, and temporal order: a disconnection 
      analysis of the role of the medial prefrontal cortex and perirhinal cortex.
PG  - 2948-57
AB  - Recognition memory requires judgments of the previous occurrence of stimuli made 
      on the basis of the relative familiarity of individual objects, or by integrating 
      information concerning objects and location, or by using recency information. The 
      present study examined the role of the medial prefrontal cortex (mPFC) and 
      perirhinal cortex (PRH) in these distinct recognition memory processes using a 
      series of behavioral tests: a novel object preference task, an object-in-place 
      task, and a temporal order memory task. Also, a disconnection procedure was used 
      to test whether these regions form components of an integrated system for 
      recognition memory. Male DA rats received bilateral lesions in the PRH or mPFC or 
      unilateral lesions placed in both cortices in either the same (PRH-mPFC IPSI) or 
      contralateral (PRH-mPFC CONTRA) hemispheres. A fifth group underwent sham surgery 
      (SHAM). In the object-in-place and temporal order memory tasks, the PRH, mPFC, 
      and PRH-mPFC CONTRA groups were significantly impaired. However, performance in 
      the novel object preference task was only impaired in the PRH group. No group was 
      impaired in the object location task. These results demonstrate that the mPFC and 
      PRH are crucial for object-in-place associational and recency discriminations, 
      whereas the PRH but not the mPFC is important for the discrimination of novel and 
      familiar individual objects. Importantly, these results provide direct support 
      for the hypothesis that to make discriminations based on associational or recency 
      information, both cortical regions operate within an integrated neural network 
      for recognition memory.
FAU - Barker, Gareth R I
AU  - Barker GR
AD  - MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, 
      Bristol BS8 1TD, United Kingdom.
FAU - Bird, Flora
AU  - Bird F
FAU - Alexander, Victoria
AU  - Alexander V
FAU - Warburton, E Clea
AU  - Warburton EC
LA  - eng
GR  - G0401403/MRC_/Medical Research Council/United Kingdom
GR  - S18861/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Animals
MH  - Entorhinal Cortex/*physiology
MH  - Exploratory Behavior/physiology
MH  - Male
MH  - Memory/physiology
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Recognition, Psychology/*physiology
MH  - Time Factors
PMC - PMC6672574
EDAT- 2007/03/16 09:00
MHDA- 2007/04/06 09:00
PMCR- 2007/09/14
CRDT- 2007/03/16 09:00
PHST- 2007/03/16 09:00 [pubmed]
PHST- 2007/04/06 09:00 [medline]
PHST- 2007/03/16 09:00 [entrez]
PHST- 2007/09/14 00:00 [pmc-release]
AID - 27/11/2948 [pii]
AID - 3194118 [pii]
AID - 10.1523/JNEUROSCI.5289-06.2007 [doi]
PST - ppublish
SO  - J Neurosci. 2007 Mar 14;27(11):2948-57. doi: 10.1523/JNEUROSCI.5289-06.2007.