PMID- 17362251
OWN - NLM
STAT- MEDLINE
DCOM- 20070518
LR  - 20070316
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 62
IP  - 4
DP  - 2007 Apr
TI  - Predictors of response to bronchial allergen challenge in 5- to 6-year-old atopic 
      children.
PG  - 401-7
AB  - BACKGROUND: The relationship between atopy and bronchial allergy in young 
      children is not completely understood. OBJECTIVE: To examine the association 
      between response to bronchial allergen challenge, immune markers of atopy and 
      other clinical characteristics in 5- to 6-year-old children. METHODS: Children 
      with positive skin test (SPT) to aeroallergen, together with a proportion of SPT 
      negative children (as controls), were recruited from a birth cohort of 198 
      children at high risk of developing atopic disease and underwent allergen 
      challenge. RESULTS: Thirty-seven children (26 atopic and 11 SPT negative), median 
      age 74.5 months, were challenged: 31 with house dust mite and six with grass 
      allergen. Only atopic children responded to challenge: n = 12/26 (46%). Wheal 
      size [odds ratio (OR) 2.5 (1.2-5.3), P = 0.01], allergen-specific immunoglobulin 
      E (IgE) [OR 3.4 (1.23-9.61), P = 0.02], total IgE [OR 8.6 (1.1-68.7), P = 0.04], 
      current wheeze [OR 12 (1.7-81.7), P = 0.006] and persistent eczema [OR 11.0 
      (1.7-68.3), P = 0.006] emerged as the strongest independent predictors of 
      response to allergen challenge. Prediction of response to allergen challenge was 
      significantly improved when immune markers of atopy, and in particular wheal 
      size, were combined with clinical characteristics. CONCLUSION: The relationship 
      between atopy and bronchial allergy is quantitative at this age. There may be 
      potential to create more powerful indicators of the presence of respiratory 
      allergy in young children when immunological markers of atopy are considered 
      quantitatively and when combined with clinical history of coexistent allergic 
      disease.
FAU - Douglas, T A
AU  - Douglas TA
AD  - Division of Clinical Sciences, Telethon Institute for Child Research, Centre for 
      Child Health Research, The University of Western Australia, Perth, WA, Australia.
FAU - Kusel, M
AU  - Kusel M
FAU - Pascoe, E M
AU  - Pascoe EM
FAU - Loh, R K S
AU  - Loh RK
FAU - Holt, P G
AU  - Holt PG
FAU - Sly, P D
AU  - Sly PD
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*administration & dosage/immunology
MH  - Bronchial Provocation Tests
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/epidemiology/*immunology
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Skin Tests
EDAT- 2007/03/17 09:00
MHDA- 2007/05/19 09:00
CRDT- 2007/03/17 09:00
PHST- 2007/03/17 09:00 [pubmed]
PHST- 2007/05/19 09:00 [medline]
PHST- 2007/03/17 09:00 [entrez]
AID - ALL1329 [pii]
AID - 10.1111/j.1398-9995.2007.01329.x [doi]
PST - ppublish
SO  - Allergy. 2007 Apr;62(4):401-7. doi: 10.1111/j.1398-9995.2007.01329.x.