PMID- 17363430
OWN - NLM
STAT- MEDLINE
DCOM- 20071130
LR  - 20071018
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1111
DP  - 2007 Sep
TI  - Dendritic cell-based vaccine against coccidioides infection.
PG  - 269-74
AB  - Coccidioides causes coccidioidomycosis in the southwestern United States. Its 
      clinical manifestations range from the primary asymptomatic to progressive 
      pulmonary and extrapulmonary disease. Because of endemicity, frequent relapse, 
      and virulent nature of Coccidioides, there is an urgent need for the development 
      of effective therapy or vaccine. It has been recognized from studies in human 
      patients and in murine models that the divergence in their susceptibility to 
      Coccidioides infection is related to differences in T cell response. Dendritic 
      cells (DCs) are most potent antigen-presenting cells that play a critical role in 
      activating naive T cells. On account of their unique immunostimulatory capacity, 
      DCs have been used for the development of immunotherapy and vaccines against 
      cancer and infectious diseases. We recently investigated the immunostimulatory 
      potential of a DC-based vaccine in a murine model against Coccidioides posadasii 
      (C. posadasii). Our results suggest that DCs act as a potent adjuvant and 
      activate protective responses in mice against C. posadasii.
FAU - Awasthi, Shanjana
AU  - Awasthi S
AD  - Department of Pharmaceutical Sciences, 1110 North Stonewall Avenue, Oklahoma 
      City, OK 73117, USA. Shanjana-Awasthi@ouhsc.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070315
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Fungal Vaccines)
SB  - IM
MH  - Animals
MH  - Coccidioides/*metabolism
MH  - Coccidioidomycosis/*immunology/metabolism/*prevention & control
MH  - Dendritic Cells/metabolism/*microbiology
MH  - Fungal Vaccines/*chemistry
MH  - Humans
MH  - Immunotherapy/methods
MH  - Mice
MH  - Microbiological Techniques/trends
MH  - T-Lymphocytes/immunology
RF  - 35
EDAT- 2007/03/17 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/03/17 09:00
PHST- 2007/03/17 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/03/17 09:00 [entrez]
AID - annals.1406.013 [pii]
AID - 10.1196/annals.1406.013 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2007 Sep;1111:269-74. doi: 10.1196/annals.1406.013. Epub 2007 
      Mar 15.