PMID- 17363674
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20071203
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 315
IP  - 5818
DP  - 2007 Mar 16
TI  - Founder effects in the assessment of HIV polymorphisms and HLA allele 
      associations.
PG  - 1583-6
AB  - Escape from T cell-mediated immune responses affects the ongoing evolution of 
      rapidly evolving viruses such as HIV. By applying statistical approaches that 
      account for phylogenetic relationships among viral sequences, we show that viral 
      lineage effects rather than immune escape often explain apparent human leukocyte 
      antigen (HLA)-mediated immune-escape mutations defined by older analysis methods. 
      Phylogenetically informed methods identified immune-susceptible locations with 
      greatly improved accuracy, and the associations we identified with these methods 
      were experimentally validated. This approach has practical implications for 
      understanding the impact of host immunity on pathogen evolution and for defining 
      relevant variants for inclusion in vaccine antigens.
FAU - Bhattacharya, Tanmoy
AU  - Bhattacharya T
AD  - Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
FAU - Daniels, Marcus
AU  - Daniels M
FAU - Heckerman, David
AU  - Heckerman D
FAU - Foley, Brian
AU  - Foley B
FAU - Frahm, Nicole
AU  - Frahm N
FAU - Kadie, Carl
AU  - Kadie C
FAU - Carlson, Jonathan
AU  - Carlson J
FAU - Yusim, Karina
AU  - Yusim K
FAU - McMahon, Ben
AU  - McMahon B
FAU - Gaschen, Brian
AU  - Gaschen B
FAU - Mallal, Simon
AU  - Mallal S
FAU - Mullins, James I
AU  - Mullins JI
FAU - Nickle, David C
AU  - Nickle DC
FAU - Herbeck, Joshua
AU  - Herbeck J
FAU - Rousseau, Christine
AU  - Rousseau C
FAU - Learn, Gerald H
AU  - Learn GH
FAU - Miura, Toshiyuki
AU  - Miura T
FAU - Brander, Christian
AU  - Brander C
FAU - Walker, Bruce
AU  - Walker B
FAU - Korber, Bette
AU  - Korber B
LA  - eng
GR  - AI27757/AI/NIAID NIH HHS/United States
GR  - AI57005/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
CIN - Science. 2007 Mar 16;315(5818):1505-7. PMID: 17363650
MH  - Alleles
MH  - Antigen Presentation
MH  - Epitopes
MH  - Evolution, Molecular
MH  - *Founder Effect
MH  - Genes, MHC Class I
MH  - Genes, Viral
MH  - HIV Infections/immunology/*virology
MH  - HIV-1/classification/*genetics/*immunology
MH  - HLA Antigens/*genetics/immunology
MH  - HLA-C Antigens/genetics
MH  - Humans
MH  - Immune Tolerance
MH  - Likelihood Functions
MH  - Mutation
MH  - Phenotype
MH  - Phylogeny
MH  - *Polymorphism, Genetic
MH  - T-Lymphocytes, Cytotoxic/immunology
EDAT- 2007/03/17 09:00
MHDA- 2007/03/30 09:00
CRDT- 2007/03/17 09:00
PHST- 2007/03/17 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2007/03/17 09:00 [entrez]
AID - 315/5818/1583 [pii]
AID - 10.1126/science.1131528 [doi]
PST - ppublish
SO  - Science. 2007 Mar 16;315(5818):1583-6. doi: 10.1126/science.1131528.