PMID- 17364081
OWN - NLM
STAT- MEDLINE
DCOM- 20070607
LR  - 20221207
IS  - 0304-4602 (Print)
IS  - 0304-4602 (Linking)
VI  - 36
IP  - 2
DP  - 2007 Feb
TI  - Seronegative spondyloarthropathy--studies from the Asia Pacific region.
PG  - 135-41
AB  - Recent therapeutic advances, in particular the use of anti-tumour necrosis factor 
      (anti-TNF) agents, have revived interest in the seronegative 
      spondyloarthropathies (SpA), a group of arthritides characterised by axial 
      skeletal involvement and the absence of rheumatoid factor. The purpose of this 
      article is to review the studies that have been done in the Asia Pacific region, 
      as a broad understanding of the scope and severity of this group of diseases 
      would enable rheumatologists and physicians in this part of the world to better 
      manage their patients. The majority of genetic studies have focused on the 
      associations of HLA-B27 with ankylosing spondylitis (AS) and SpA, while a few 
      studies examined the associations of the CARD, IL-1, LMP2, TAP and TGF with AS. 
      There are a handful of studies on the immunological responses to bacteria and 
      cytokine levels in AS. The onset and clinical features of SpA have been reported 
      from most countries in the region, but no data on patient outcomes, using current 
      measurement tools such as the Bath Ankylosing Spondylitis Disease Activity index 
      (BASDAI), is available. Validation of these instruments of measurement as well as 
      classification criteria in different ethnic populations is necessary where no 
      prior data exist. Future studies will likely be focused on better clinical 
      characterisation of patient cohorts, particularly with regard to the use of 
      currently used measurement tools for disease activity and spinal function and 
      mobility, and the identification of the need for biologic therapy in each 
      country.
FAU - Howe, Hwee Siew
AU  - Howe HS
AD  - Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 
      Singapore. Hwee_Siew_Howe@ttsh.com.sg
FAU - Zhao, Like
AU  - Zhao L
FAU - Song, Yeong Wook
AU  - Song YW
FAU - Springer, Lauren
AU  - Springer L
FAU - Edmonds, John
AU  - Edmonds J
FAU - Gu, Jieruo
AU  - Gu J
FAU - Yu, David T Y
AU  - Yu DT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Arthritis/epidemiology/genetics/immunology/therapy
MH  - Asian People
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/genetics
MH  - Humans
MH  - Sensitivity and Specificity
MH  - *Spinal Diseases/epidemiology/genetics/immunology/therapy
MH  - Spondylitis, Ankylosing/genetics/immunology
MH  - Transforming Growth Factor beta1/immunology
RF  - 123
EDAT- 2007/03/17 09:00
MHDA- 2007/06/08 09:00
CRDT- 2007/03/17 09:00
PHST- 2007/03/17 09:00 [pubmed]
PHST- 2007/06/08 09:00 [medline]
PHST- 2007/03/17 09:00 [entrez]
PST - ppublish
SO  - Ann Acad Med Singap. 2007 Feb;36(2):135-41.