PMID- 17364748
OWN - NLM
STAT- MEDLINE
DCOM- 20070410
LR  - 20151119
IS  - 0271-3683 (Print)
IS  - 0271-3683 (Linking)
VI  - 32
IP  - 2
DP  - 2007 Feb
TI  - Does treated systemic hypertension affect progression of optic nerve damage in 
      glaucoma suspects?
PG  - 153-60
AB  - PURPOSE: To evaluate whether treatment of systemic hypertension has an effect on 
      progression of optic nerve parameters in glaucoma suspects using confocal 
      scanning laser ophthalmoscopy. METHODS: Two hundred eyes of 103 glaucoma suspect 
      patients were included in this retrospective cohort study. Thirty-one patients 
      (of whom 59 eyes were included in the study) had systemic hypertension under 
      treatment (based on medical history). The remaining 72 age-matched normotensive 
      controls (of whom 141 eyes were included in the study) were not on 
      blood-pressure-lowering medications. Each patient had a follow-up period of at 
      least 4 years with a minimum of four Heidelberg retinal tomograph tests (one 
      baseline and three follow-up scans). The slopes of progression of optic nerve 
      head parameters with time were studied and compared between these two groups 
      using mixed effects regression models. RESULTS: Patients with systemic 
      hypertension showed a statistically significant increase in cup area (slope 0.2, 
      p = 0.03), cup-to-disk area ratio (slope 0.01, p = 0.007), and decrease in rim 
      area (slope -0.4, p = 0.03), rim-to-disk area ratio (slope -0.01, p = 0.005), and 
      global Retinal Nerve Fiber Layer (RNFL) thickness (p = 0.008) with time. The 
      differences in slopes of progression of many parameters between hypertensives and 
      normotensives were statistically significant. CONCLUSIONS: Systemic hypertension 
      treated with hypotensive medications may be a risk factor for increased 
      progression of optic nerve parameters in glaucoma suspects compared with 
      age-matched normotensive subjects.
FAU - Punjabi, Omar S
AU  - Punjabi OS
AD  - Department of Ophthalmology, University of California, San Francisco (UCSF) 
      School of Medicine, San Francisco, California, USA.
FAU - Stamper, Robert L
AU  - Stamper RL
FAU - Bostrom, Alan G
AU  - Bostrom AG
FAU - Lin, Shan C
AU  - Lin SC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Antihypertensive Agents/*therapeutic use
MH  - Disease Progression
MH  - Female
MH  - Gonioscopy
MH  - Humans
MH  - Hypertension/*drug therapy/physiopathology
MH  - Intraocular Pressure
MH  - Lasers
MH  - Male
MH  - Middle Aged
MH  - Ocular Hypertension/*physiopathology
MH  - Ophthalmoscopy/methods
MH  - Optic Disk/pathology
MH  - Optic Nerve Diseases/*physiopathology
MH  - Retrospective Studies
EDAT- 2007/03/17 09:00
MHDA- 2007/04/11 09:00
CRDT- 2007/03/17 09:00
PHST- 2007/03/17 09:00 [pubmed]
PHST- 2007/04/11 09:00 [medline]
PHST- 2007/03/17 09:00 [entrez]
AID - 771401992 [pii]
AID - 10.1080/02713680601114955 [doi]
PST - ppublish
SO  - Curr Eye Res. 2007 Feb;32(2):153-60. doi: 10.1080/02713680601114955.