PMID- 17365850
OWN - NLM
STAT- MEDLINE
DCOM- 20070620
LR  - 20131121
IS  - 0953-7104 (Print)
IS  - 0953-7104 (Linking)
VI  - 18
IP  - 1
DP  - 2007 Feb
TI  - Effects of beta2-glycoprotein-I on platelet aggregation in cord versus adult 
      whole blood.
PG  - 24-8
AB  - We present a peculiarity of the neonatal hemostatic system that might contribute 
      to establish a procoagulant readiness in neonatal blood by sensitizing neonatal 
      platelets for ADP stimulation. beta2-glycoprotein-I (beta2-GP-I) is a plasma 
      constituent capable of suppressing ADP-induced platelet aggregation. We found 
      significant lower levels of beta2-GP-I in cord vs. adult plasma (120 +/- 27 vs. 
      180 +/- 37 microg/mL, P<0.001). We demonstrate dose-dependent inhibition of 
      ADP-induced platelet aggregation in cord whole blood (WB) in the presence of 
      increasing amounts of beta2-GP-I, evaluated by means of WB aggregometry employing 
      the impedance method. Particularly, raising the beta2-GP-I concentration in cord 
      WB from neonatal level up to the respective adult value caused significant 
      reduction of amplitude (from 9.5 +/- 2.7 to 2.8 +/- 0.9 Omega, P<0.001) and of 
      slope (from 5.9 +/- 2.4 to 1.89 +/- 0.9 Omega/min, P<0.001), and a significant 
      prolongation of the aggregation time (from 51.8 +/- 22.9 to 110.8 +/- 60.3 s, 
      P<0.001). In conclusion, physiological low levels of beta2-GP-I in cord WB cause 
      enhanced responsiveness of neonatal platelets to ADP stimulation. This mechanism 
      might help to explain the clinically observed well-functioning hemostasis in 
      neonates.
FAU - Cvirn, Gerhard
AU  - Cvirn G
AD  - Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria. 
      gerhard.cvirn@meduni-graz.at
FAU - Gallistl, Siegfried
AU  - Gallistl S
FAU - Koestenberger, Martin
AU  - Koestenberger M
FAU - Kutschera, Joerg
AU  - Kutschera J
FAU - Ferstl, Ulrika
AU  - Ferstl U
FAU - Kellner, Josef
AU  - Kellner J
FAU - Jurgens, Gunther
AU  - Jurgens G
FAU - Gries, Anna
AU  - Gries A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Platelets
JT  - Platelets
JID - 9208117
RN  - 0 (beta 2-Glycoprotein I)
RN  - 61D2G4IYVH (Adenosine Diphosphate)
SB  - IM
MH  - Adenosine Diphosphate/pharmacology
MH  - Adult
MH  - Age Factors
MH  - Female
MH  - Fetal Blood/*physiology
MH  - *Hemostasis
MH  - Humans
MH  - Infant, Newborn/*blood
MH  - Male
MH  - *Platelet Aggregation/drug effects
MH  - beta 2-Glycoprotein I/analysis/*pharmacology/physiology
EDAT- 2007/03/17 09:00
MHDA- 2007/06/21 09:00
CRDT- 2007/03/17 09:00
PHST- 2007/03/17 09:00 [pubmed]
PHST- 2007/06/21 09:00 [medline]
PHST- 2007/03/17 09:00 [entrez]
AID - 770734491 [pii]
AID - 10.1080/09537100600800529 [doi]
PST - ppublish
SO  - Platelets. 2007 Feb;18(1):24-8. doi: 10.1080/09537100600800529.