PMID- 17367707
OWN - NLM
STAT- MEDLINE
DCOM- 20070411
LR  - 20071203
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 17
IP  - 3
DP  - 2007 Mar
TI  - The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response 
      following changes in dietary fat intake in a healthy population.
PG  - 224-9
AB  - Our goal was to determine whether the presence of the -516C/T polymorphism in the 
      APOB gene promoter modifies the lipid response to changes in the amount and 
      quality of dietary fat. We studied 97 young healthy volunteers (70 males and 27 
      females), 62 homozygotes for the -516C allele (C/C) (47 males and 15 females), 34 
      heterozygotes for the -516T allele (C/T) (22 males and 12 females) and one male 
      homozygote for the -516T allele (T/T). Subjects consumed three different diets in 
      successive 4-week dietary periods. During the first 28 days, all subjects 
      consumed a saturated fatty acid (SFA)-rich diet (38% fat and 20% SFA). Then, 
      using a randomized crossover design, subjects were assigned a carbohydrate 
      (CHO)-rich diet (30% fat and 55% carbohydrate) or a monounsaturated fatty acid 
      (MUFA)-rich diet (38% fat and 22% MUFA). At the end of each dietary period, 
      plasma concentrations of triacylglycerols and of total, LDL, and HDL cholesterol 
      were measured. No differences in plasma lipid and apolipoprotein response were 
      found after changes in dietary fat intake in relation to the -516C/T polymorphism 
      in our study population. In conclusion, our data suggest that the APOB -516C/T 
      polymorphism has no effect on the lipid profile after changes in dietary fat 
      intake in a healthy population.
FAU - Perez-Martinez, Pablo
AU  - Perez-Martinez P
AD  - Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Avda 
      Menendez Pidal, s/n. 14004 Cordoba, Spain.
FAU - Perez-Jimenez, Francisco
AU  - Perez-Jimenez F
FAU - Ordovas, Jose M
AU  - Ordovas JM
FAU - Bellido, Cecilia
AU  - Bellido C
FAU - Moreno, Juan A
AU  - Moreno JA
FAU - Gomez, Purificacion
AU  - Gomez P
FAU - Marin, Carmen
AU  - Marin C
FAU - Fernandez de la Puebla, Rafael Angel
AU  - Fernandez de la Puebla RA
FAU - Paniagua, Juan Antonio
AU  - Paniagua JA
FAU - Lopez-Miranda, Jose
AU  - Lopez-Miranda J
LA  - eng
GR  - HL54776/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20060320
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Apolipoproteins)
RN  - 0 (Apolipoproteins B)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Apolipoproteins/blood
MH  - Apolipoproteins B/*genetics
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Lipids/*blood
MH  - Male
MH  - *Polymorphism, Genetic
EDAT- 2007/03/21 09:00
MHDA- 2007/04/12 09:00
CRDT- 2007/03/21 09:00
PHST- 2005/05/02 00:00 [received]
PHST- 2005/11/02 00:00 [revised]
PHST- 2005/11/02 00:00 [accepted]
PHST- 2007/03/21 09:00 [pubmed]
PHST- 2007/04/12 09:00 [medline]
PHST- 2007/03/21 09:00 [entrez]
AID - S0939-4753(05)00254-1 [pii]
AID - 10.1016/j.numecd.2005.11.010 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2007 Mar;17(3):224-9. doi: 
      10.1016/j.numecd.2005.11.010. Epub 2006 Mar 20.