PMID- 1736832
OWN - NLM
STAT- MEDLINE
DCOM- 19920312
LR  - 20131121
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 19
IP  - 2
DP  - 1992 Feb
TI  - [Preoperative role of angiotensin II induced hypertension chemotherapy (IHC) in 
      advanced gastric carcinoma].
PG  - 203-9
AB  - To investigate the role of preoperative IHC in advanced gastric carcinoma, 
      clinical, surgical and pathological stagings of 13 patients were analysed 
      retrospectively. These patients were treated with a 3-drug combination of 
      adriamycin, 5-fluorouracil and mitomycin C under angiotensin II induced 
      hypertensive state. The response rate was 69.2% and mean survival time was 850.2 
      days. "Down staging" in surgical stage was observed in 5 out of 13 cases (38.3%), 
      and in pathological stage 7 cases (53.8%) "down staging" was achieved. Mean 
      survival time of "pathological down-staging" cases was significantly longer than 
      that of "non-down-staging" cases (1039.6 vs 322.1 days, p less than 0.01, 
      generalized Wilcoxon test). IHC brings selective increase of drug delivery to 
      tumor tissue, and will be useful as preoperative chemotherapy in advanced gastric 
      carcinoma in terms of "down staging".
FAU - Sugiyama, K
AU  - Sugiyama K
AD  - Department of Clinical Cancer Chemotherapy, Tohoku University, Sendai, Japan.
FAU - Sato, H
AU  - Sato H
FAU - Ishizuka, K
AU  - Ishizuka K
FAU - Hoshi, M
AU  - Hoshi M
FAU - Urushiyama, M
AU  - Urushiyama M
FAU - Wakui, A
AU  - Wakui A
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 11128-99-7 (Angiotensin II)
RN  - 50SG953SK6 (Mitomycin)
RN  - 80168379AG (Doxorubicin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiotensin II/pharmacology/*therapeutic use
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Blood Pressure/*drug effects
MH  - Combined Modality Therapy
MH  - Doxorubicin/administration & dosage
MH  - Female
MH  - Fluorouracil/administration & dosage
MH  - Gastroscopy
MH  - Humans
MH  - *Hyperthermia, Induced
MH  - Male
MH  - Middle Aged
MH  - Mitomycin/administration & dosage
MH  - Preoperative Care
MH  - Retrospective Studies
MH  - Stomach Neoplasms/drug therapy/pathology/*therapy
EDAT- 1992/02/01 00:00
MHDA- 1992/02/01 00:01
CRDT- 1992/02/01 00:00
PHST- 1992/02/01 00:00 [pubmed]
PHST- 1992/02/01 00:01 [medline]
PHST- 1992/02/01 00:00 [entrez]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 1992 Feb;19(2):203-9.