PMID- 17368527
OWN - NLM
STAT- MEDLINE
DCOM- 20070820
LR  - 20181113
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 86
IP  - 4
DP  - 2007 Apr
TI  - Serotonin receptor involvement in effects of restraint on female rat lordosis 
      behavior.
PG  - 631-6
AB  - Ovariectomized Fischer (CDF-344) rats, with bilateral cannulae in the mediobasal 
      hypothalamus (MBH) near the ventromedial nucleus of the hypothalamus (VMN), were 
      used to test the hypothesis that serotonin receptors in the VMN contribute to the 
      lordosis-inhibiting effects of mild restraint. Rats were hormonally primed with 
      10 microg estradiol benzoate (EB) followed 48 h later with sesame seed oil. Four 
      to six hours later (during the dark portion of the light-dark cycle), rats were 
      pretested for sexual behavior. Thereafter, they were infused with saline, 2 
      microg of the serotonin (5-HT) 2 receptor agonist, 
      (+/-)-2,5-dimethoxy-4-iodophenyl-2-aminopropane HCl (DOI), or 1 microg of the 
      5-HT(1A) receptor antagonist, 
      N-2[4-(2-methoxyphenyl)-1-piperazinyl]ethyl-N-(2-pyridinyl) 
      cyclohexanecarboxamide trihydrochloride (WAY100635). After a 5 min restraint, 
      rats were tested for sexual receptivity. Rats infused with saline showed a 
      significant decline in lordosis behavior after restraint. Infusion with either 
      DOI or WAY100635 attenuated these effects of restraint. These findings extend 
      earlier observations that the lordosis-disruptive effects of mild restraint 
      include activation of 5-HT(1A) receptors in the VMN and are the first to 
      implicate VMN 5-HT(2) receptors in protection against mild restraint.
FAU - Uphouse, Lynda
AU  - Uphouse L
AD  - Department of Biology, Texas Woman's University, Denton, TX 76204, USA. 
      Luphouse@mail.twu.edu
FAU - Hiegel, Cindy
AU  - Hiegel C
FAU - Perez, Erika
AU  - Perez E
FAU - Guptarak, Jutatip
AU  - Guptarak J
LA  - eng
GR  - R25 GM055380/GM/NIGMS NIH HHS/United States
GR  - R01 HD028419/HD/NICHD NIH HHS/United States
GR  - R01 HD028419-12/HD/NICHD NIH HHS/United States
GR  - GM 55380/GM/NIGMS NIH HHS/United States
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070216
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Amphetamines)
RN  - 0 (Piperazines)
RN  - 0 (Pyridines)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Receptors, Serotonin, 5-HT2)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 1S4CJB5ZGN (estradiol 3-benzoate)
RN  - 4TI98Z838E (Estradiol)
RN  - 71IH826FEG 
      (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide)
RN  - OOM10GW9UE (4-iodo-2,5-dimethoxyphenylisopropylamine)
SB  - IM
MH  - Amphetamines/administration & dosage
MH  - Animals
MH  - Estradiol/administration & dosage/analogs & derivatives
MH  - Female
MH  - Ovariectomy
MH  - Piperazines/administration & dosage
MH  - Posture
MH  - Pyridines/administration & dosage
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptor, Serotonin, 5-HT1A/drug effects/physiology
MH  - Receptors, Serotonin/drug effects/*physiology
MH  - Receptors, Serotonin, 5-HT2/drug effects/physiology
MH  - Restraint, Physical/*physiology
MH  - Serotonin Antagonists/administration & dosage
MH  - Serotonin Receptor Agonists/administration & dosage
MH  - Sexual Behavior, Animal/drug effects/*physiology
MH  - Ventromedial Hypothalamic Nucleus/anatomy & histology/drug effects/physiology
PMC - PMC2043475
MID - NIHMS25892
EDAT- 2007/03/21 09:00
MHDA- 2007/08/21 09:00
PMCR- 2008/04/01
CRDT- 2007/03/21 09:00
PHST- 2006/06/19 00:00 [received]
PHST- 2007/01/22 00:00 [revised]
PHST- 2007/02/07 00:00 [accepted]
PHST- 2007/03/21 09:00 [pubmed]
PHST- 2007/08/21 09:00 [medline]
PHST- 2007/03/21 09:00 [entrez]
PHST- 2008/04/01 00:00 [pmc-release]
AID - S0091-3057(07)00078-0 [pii]
AID - 10.1016/j.pbb.2007.02.007 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2007 Apr;86(4):631-6. doi: 10.1016/j.pbb.2007.02.007. 
      Epub 2007 Feb 16.