PMID- 17368617
OWN - NLM
STAT- MEDLINE
DCOM- 20070726
LR  - 20141120
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 565
IP  - 1-3
DP  - 2007 Jun 22
TI  - Tianeptine increases brain-derived neurotrophic factor expression in the rat 
      amygdala.
PG  - 68-75
AB  - Chronic restraint stress affects hippocampal and amygdalar synaptic plasticity as 
      determined by electrophysiological, morphological and behavioral measures, 
      changes that are inhibited by some but not all antidepressants. The efficacy of 
      some classes of antidepressants is proposed to involve increased phosphorylation 
      of cAMP response element binding protein (CREB), leading to increased expression 
      of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF). 
      Conversely, some studies suggest that acute and chronic stress downregulate BDNF 
      expression and activity. Accordingly, the aim of the current study was to examine 
      total and phosphorylated CREB (pCREB), as well as BDNF mRNA and protein levels in 
      the hippocampus and amygdala of rats subjected to chronic restraint stress in the 
      presence and absence of the antidepressant tianeptine. In the hippocampus, 
      chronic restraint stress increased pCREB levels without affecting BDNF mRNA or 
      protein expression. Tianeptine administration had no effect upon these measures 
      in the hippocampus. In the amygdala, BDNF mRNA expression was not modulated in 
      chronic restraint stress rats given saline in spite of increased pCREB levels. 
      Conversely, BDNF mRNA levels were increased in the amygdala of chronic restraint 
      stress/tianeptine rats in the absence of changes in pCREB levels when compared to 
      non-stressed controls. Amygdalar BDNF protein increased while pCREB levels 
      decreased in tianeptine-treated rats irrespective of stress conditions. 
      Collectively, these results demonstrate that tianeptine concomitantly decreases 
      pCREB while increasing BDNF expression in the rat amygdala, increases in 
      neurotrophic factor expression that may participate in the enhancement of 
      amygdalar synaptic plasticity mediated by tianeptine.
FAU - Reagan, Lawrence P
AU  - Reagan LP
AD  - Department of Pharmacology, Physiology and Neuroscience, University of South 
      Carolina School of Medicine, 6439 Garner's Ferry Road, D40, Columbia, SC 29208, 
      United States. lpreagan@gw.med.sc.edu
FAU - Hendry, Robert M
AU  - Hendry RM
FAU - Reznikov, Leah R
AU  - Reznikov LR
FAU - Piroli, Gerardo G
AU  - Piroli GG
FAU - Wood, Gwendolyn E
AU  - Wood GE
FAU - McEwen, Bruce S
AU  - McEwen BS
FAU - Grillo, Claudia A
AU  - Grillo CA
LA  - eng
GR  - MH41256/MH/NIMH NIH HHS/United States
GR  - MH58911/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070220
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Thiazepines)
RN  - 0T493YFU8O (tianeptine)
SB  - IM
MH  - Amygdala/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/analysis/*genetics
MH  - Cyclic AMP Response Element-Binding Protein/analysis
MH  - Gene Expression Regulation/*drug effects
MH  - Hippocampus/chemistry/metabolism
MH  - Male
MH  - Phosphorylation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Restraint, Physical
MH  - Stress, Psychological/*metabolism
MH  - Thiazepines/*pharmacology
EDAT- 2007/03/21 09:00
MHDA- 2007/07/27 09:00
CRDT- 2007/03/21 09:00
PHST- 2006/10/18 00:00 [received]
PHST- 2007/02/05 00:00 [revised]
PHST- 2007/02/06 00:00 [accepted]
PHST- 2007/03/21 09:00 [pubmed]
PHST- 2007/07/27 09:00 [medline]
PHST- 2007/03/21 09:00 [entrez]
AID - S0014-2999(07)00199-9 [pii]
AID - 10.1016/j.ejphar.2007.02.023 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2007 Jun 22;565(1-3):68-75. doi: 10.1016/j.ejphar.2007.02.023. 
      Epub 2007 Feb 20.