PMID- 17370149
OWN - NLM
STAT- MEDLINE
DCOM- 20070504
LR  - 20221212
IS  - 1424-7860 (Print)
IS  - 0036-7672 (Linking)
VI  - 137
IP  - 7-8
DP  - 2007 Feb 24
TI  - Association of HLA-DQB1 gene polymorphisms with outcomes of HBV infection in 
      Chinese Han population.
PG  - 114-20
AB  - BACKGROUND: Host genetic factors and environmental factors including hepatitis B 
      virus (HBV) genotype are widely studied for the different outcomes of HBV 
      infection. Human leukocyte antigen (HLA) plays an important role in the 
      immunological reaction to HBV infection. AIMS: To explore whether the HLA-DQB1 
      allele polymorphisms are associated with the outcome of HBV infection in a 
      Chinese Han population. PATIENTS: One hundred and thirty three HBV subjects with 
      spontaneous recovery and 151 chronic hepatitis B patients were recruited into 
      this case-control study in the Beijing area of China. METHODS: Sequence specific 
      primer-polymerase chain reaction (SSP-PCR) was used to detect 13 alleles of 
      HLA-DQB1 gene and 13 alleles of HLA-DRB1 gene. Multivariate logistic regression 
      model was performed to detect the association of candidate factors with outcome 
      of HBV infection by SAS 9.1.2 software package. RESULTS: The frequency of 
      HLA-DQB1*0502 allele in the chronic hepatitis B group was significantly higher 
      than that in the group with spontaneous recovery independent of HLA-DRB1 (odds 
      ratio 95%CI 1.8-190). In this study there was no evidence to indicate that 
      cigarette smoking or alcohol consumption was associated with the outcome of HBV 
      infection. CONCLUSION: HLA-DQB1*0502 is independently associated with the outcome 
      of HBV infection and is one host genetic factor affecting HBV infection outcome. 
      At the same time, we can not rule out the possibility that excluded genes and 
      alleles may also affect outcome.
FAU - Zhu, Xi-Lin
AU  - Zhu XL
AD  - National Laboratory of Medical Molecular Biology, Institute of Basic Medical 
      Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, 
      Beijing, China.
FAU - Du, Te
AU  - Du T
FAU - Li, Jun-Hong
AU  - Li JH
FAU - Lu, Liang-Ping
AU  - Lu LP
FAU - Guo, Xin-Hui
AU  - Guo XH
FAU - Gao, Ji-Rong
AU  - Gao JR
FAU - Gou, Chun-Yan
AU  - Gou CY
FAU - Li, Zhuo
AU  - Li Z
FAU - Liu, Ying
AU  - Liu Y
FAU - Li, Hui
AU  - Li H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Hepatitis B/*genetics
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - *Polymorphism, Genetic
EDAT- 2007/03/21 09:00
MHDA- 2007/05/05 09:00
CRDT- 2007/03/21 09:00
PHST- 2007/03/21 09:00 [pubmed]
PHST- 2007/05/05 09:00 [medline]
PHST- 2007/03/21 09:00 [entrez]
AID - smw-11428 [pii]
AID - 10.4414/smw.2007.11428 [doi]
PST - ppublish
SO  - Swiss Med Wkly. 2007 Feb 24;137(7-8):114-20. doi: 10.4414/smw.2007.11428.