PMID- 17370236
OWN - NLM
STAT- MEDLINE
DCOM- 20071025
LR  - 20181201
IS  - 0260-437X (Print)
IS  - 0260-437X (Linking)
VI  - 27
IP  - 5
DP  - 2007 Sep-Oct
TI  - Developmental toxic effects of N-ethyl-2-pyrrolidone administered orally to rats.
PG  - 491-7
AB  - The developmental toxicity of N-ethyl-2-pyrrolidone (NEP) was studied in 
      Sprague-Dawley rats after oral administration. Pregnant rats were given NEP at 
      doses of 0 (distilled water), 50, 250, 500 and 750 mg kg(-1) day(-1), by gavage 
      (5 ml kg(-1)), on gestational days (GD) 6-20. Maternal toxicity, as evidenced by 
      reduction in body weight gain and food consumption, was observed in all NEP 
      groups at the beginning of treatment (GD 6-9). The incidence of resorptions was 
      significantly increased at 500 mg kg(-1) day(-1), and reached 83% at 750 mg 
      kg(-1) day(-1). There was a dose-related decrease in fetal weight, which was 
      significantly lower than control at 250 mg kg(-1) day(-1) and higher doses. The 
      incidence of malformed fetuses per litter and the number of litters with 
      malformed fetuses were significantly increased at 500 and 750 mg kg(-1) day(-1). 
      Malformations mainly consisted of edema, anal atresia with absent tail, 
      cardiovascular defects and fused cervical arches. Ossification of skull bones and 
      sternebrae was significantly reduced at 500 and 750 mg kg(-1) day(-1). The 
      incidence of supernumerary ribs was significantly elevated at 250 mg kg(-1) 
      day(-1) and higher doses. In conclusion, NEP administered by gavage is 
      embryotoxic and teratogenic at maternal toxic doses.
CI  - (c) 2007 John Wiley & Sons, Ltd.
FAU - Saillenfait, A M
AU  - Saillenfait AM
AD  - Institut National de Recherche et de Securite, Avenue de Bourgogne, B.P. 27, 
      54501 Vandoeuvre, France. anne-marie.saillenfait@inrs.fr
FAU - Gallissot, F
AU  - Gallissot F
FAU - Sabate, J P
AU  - Sabate JP
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Appl Toxicol
JT  - Journal of applied toxicology : JAT
JID - 8109495
RN  - 0 (N-ethyl-2-pyrrolidone)
RN  - 0 (Pyrrolidinones)
RN  - 44YRR34555 (Levetiracetam)
RN  - JR9CE63FPM (N-methylpyrrolidone)
RN  - ZH516LNZ10 (Piracetam)
SB  - IM
MH  - Abnormalities, Drug-Induced
MH  - Administration, Oral
MH  - Animals
MH  - Female
MH  - Fetus/*drug effects
MH  - Levetiracetam
MH  - Piracetam/analogs & derivatives/toxicity
MH  - Pregnancy
MH  - Pyrrolidinones/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2007/03/21 09:00
MHDA- 2007/10/27 09:00
CRDT- 2007/03/21 09:00
PHST- 2007/03/21 09:00 [pubmed]
PHST- 2007/10/27 09:00 [medline]
PHST- 2007/03/21 09:00 [entrez]
AID - 10.1002/jat.1237 [doi]
PST - ppublish
SO  - J Appl Toxicol. 2007 Sep-Oct;27(5):491-7. doi: 10.1002/jat.1237.