PMID- 17371856
OWN - NLM
STAT- MEDLINE
DCOM- 20070815
LR  - 20181113
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 75
IP  - 6
DP  - 2007 Jun
TI  - Legionella pneumophila infection up-regulates dendritic cell Toll-like receptor 2 
      (TLR2)/TLR4 expression and key maturation markers.
PG  - 3205-8
AB  - Dendritic cells (DCs) have a critical role in linking innate to adaptive 
      immunity, and this transition is regulated by the up-regulation of costimulatory 
      and major histocompatibility complex (MHC) molecules as well as Toll-like 
      receptors. These changes in DCs have been observed to occur following microbial 
      infection, and in the present study, we examined the effect of Legionella 
      pneumophila infection on the expression of these DC markers. We showed that bone 
      marrow-derived DC cultures from BALB/c mice infected with live L. pneumophila 
      resulted in the up-regulation of Toll-like receptors 2 and 4 and the activation 
      of CD40, CD86, and MHC class I/II molecules.
FAU - Rogers, James
AU  - Rogers J
AD  - Department of Molecular Medicine, University of South Florida, 12901 Bruce B. 
      Downs Boulevard, Tampa, FL 33612-4799, USA.
FAU - Hakki, Amal
AU  - Hakki A
FAU - Perkins, Izabella
AU  - Perkins I
FAU - Newton, Catherine
AU  - Newton C
FAU - Widen, Ray
AU  - Widen R
FAU - Burdash, Nicholas
AU  - Burdash N
FAU - Klein, Thomas
AU  - Klein T
FAU - Friedman, Herman
AU  - Friedman H
LA  - eng
PT  - Journal Article
DEP - 20070319
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Biomarkers)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Dendritic Cells/metabolism/*microbiology
MH  - Legionella pneumophila/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Toll-Like Receptor 2/*physiology
MH  - Toll-Like Receptor 4/*metabolism
MH  - Up-Regulation
PMC - PMC1932887
EDAT- 2007/03/21 09:00
MHDA- 2007/08/19 09:00
PMCR- 2007/10/01
CRDT- 2007/03/21 09:00
PHST- 2007/03/21 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/03/21 09:00 [entrez]
PHST- 2007/10/01 00:00 [pmc-release]
AID - IAI.01950-06 [pii]
AID - 1950-06 [pii]
AID - 10.1128/IAI.01950-06 [doi]
PST - ppublish
SO  - Infect Immun. 2007 Jun;75(6):3205-8. doi: 10.1128/IAI.01950-06. Epub 2007 Mar 19.