PMID- 17372387
OWN - NLM
STAT- MEDLINE
DCOM- 20070629
LR  - 20191026
IS  - 0914-9465 (Print)
IS  - 0914-9465 (Linking)
VI  - 69
IP  - 5
DP  - 2006 Dec
TI  - Ocular defense mechanisms with special reference to the demonstration and 
      functional morphology of the conjunctiva-associated lymphoid tissue in Japanese 
      monkeys.
PG  - 311-22
AB  - In order to define the histological components of ocular defense, the conjunctiva 
      in Japanese monkeys was studied using a whole mount method, light microscopy, and 
      electron microscopy. We investigated the distribution of the 
      conjunctiva-associated lymphoid tissue (CALT) using stereoscopic observations of 
      the conjunctiva immunostained with human leukocyte antigen (HLA)-DR antibody and 
      /or stained with alcian-blue. The outer surface of the conjunctival fornix was 
      lined by sheets of mucus secreting goblet cells, with small epithelial patches 
      without goblet cells, scattered among them. The patches, termed CALT, consisted 
      of flattened epithelial cells, intraepithelial lymphocytes and dendritic cells, 
      and lymphoid follicles with a germinal center. The CALT in Japanese monkeys was 
      fundamentally similar in structure to those found in other animal species. CALT 
      patches ranged in size ranging from 200 microm to 300 microm in diameter. The 
      number of patches varied from 20 to 40 in the superior eyelid and 10 to 20 in the 
      inferior eyelid. Latex microspheres administrated as eye drops were selectively 
      taken up first by flattened associated epithelial cells covering the surfaces of 
      CALT patches and then by intraepithelial dendritic cells of the CALT. These 
      morphological findings show that CALT patches in the eyelids of primates are 
      focal sites for particulate uptake and contact with lymphoid constituents, 
      indicating that they are inductive sites for the common mucosal immune system as 
      well as important components in ocular defense.
FAU - Kageyama, Makoto
AU  - Kageyama M
AD  - Department of Ophthalmology, Faculty of Medicine, Oita University, Yufu, Oita, 
      Japan.
FAU - Nakatsuka, Kazuo
AU  - Nakatsuka K
FAU - Yamaguchi, Takeshi
AU  - Yamaguchi T
FAU - Owen, Robert L
AU  - Owen RL
FAU - Shimada, Tatsuo
AU  - Shimada T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Arch Histol Cytol
JT  - Archives of histology and cytology
JID - 8806082
SB  - IM
MH  - Animals
MH  - Conjunctiva/*cytology/*immunology/ultrastructure
MH  - Depth Perception
MH  - Epithelium/immunology/ultrastructure
MH  - Eyelids/cytology/immunology/ultrastructure
MH  - Female
MH  - Lymphoid Tissue/*cytology/*immunology/ultrastructure
MH  - Macaca/*immunology
MH  - Male
MH  - Microscopy, Electron, Scanning
MH  - Microscopy, Electron, Transmission
EDAT- 2007/03/21 09:00
MHDA- 2007/06/30 09:00
CRDT- 2007/03/21 09:00
PHST- 2007/03/21 09:00 [pubmed]
PHST- 2007/06/30 09:00 [medline]
PHST- 2007/03/21 09:00 [entrez]
AID - JST.JSTAGE/aohc/69.311 [pii]
AID - 10.1679/aohc.69.311 [doi]
PST - ppublish
SO  - Arch Histol Cytol. 2006 Dec;69(5):311-22. doi: 10.1679/aohc.69.311.