PMID- 17373675
OWN - NLM
STAT- MEDLINE
DCOM- 20070921
LR  - 20220331
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 82
IP  - 8
DP  - 2007 Aug
TI  - Follicular dendritic cell sarcoma: a report of 14 cases and a review of the 
      literature.
PG  - 725-8
AB  - Follicular dendritic cell sarcomas (FDCS) are grouped with the histiocytic and 
      dendritic cell neoplasms. The natural history and response to different 
      treatments have not been well established. The cases of 14 patients with FDCS who 
      were seen at M. D. Anderson between 1995 and 2005 were reviewed. Median patient 
      age was 48 years (range, 25-69 years). Histologically, four cases showed 
      low-grade features, three cases showed low-grade features with focal high-grade 
      features, and five cases showed high-grade features. Tumors were positive for 
      CD21, CD23, and CD35 in 83, 90, and 44% of cases, respectively. Twelve (92%) of 
      13 tumors were strongly positive for epidermal growth factor receptor. 
      Information on initial treatment was available in 11 patients, which included 
      surgery alone in one patient, surgery and radiation in two, surgery and 
      chemotherapy in one, chemotherapy alone in three, chemotherapy and radiation in 
      one, surgery followed by radiation and chemotherapy in three patients. In eight 
      patients the initial chemotherapy regimen was cyclophosphamide, doxorubicin, 
      vincristine, and prednisone. Complete remission was achieved in 7 (63%) of 11 
      patients. Ten patients were alive at a median follow up of 22 months, 3 (23%) of 
      13 had no evidence of disease, and 7 (53%) of 13 patients were alive with 
      disease. Follicular sarcoma is an aggressive neoplasm. Although most of the 
      patients initially responded to treatment, the majority of them (81%) relapsed. A 
      better understanding of the biology of FDCS could guide our efforts in the 
      development of new treatment modalities for this rare disease.
FAU - Soriano, Andres O
AU  - Soriano AO
AD  - Department of Lymphoma and Myeloma, University of Texas M.D. Anderson Cancer 
      Center, Houston, Texas 77030, USA.
FAU - Thompson, Michael A
AU  - Thompson MA
FAU - Admirand, Joan H
AU  - Admirand JH
FAU - Fayad, Luis E
AU  - Fayad LE
FAU - Rodriguez, Alma M
AU  - Rodriguez AM
FAU - Romaguera, Jorge E
AU  - Romaguera JE
FAU - Hagemeister, Fredrick B
AU  - Hagemeister FB
FAU - Pro, Barbara
AU  - Pro B
LA  - eng
GR  - CA16672/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
SB  - IM
MH  - Adult
MH  - Aged
MH  - Dendritic Cells, Follicular/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Sarcoma/*pathology
MH  - Treatment Outcome
RF  - 18
EDAT- 2007/03/22 09:00
MHDA- 2007/09/22 09:00
CRDT- 2007/03/22 09:00
PHST- 2007/03/22 09:00 [pubmed]
PHST- 2007/09/22 09:00 [medline]
PHST- 2007/03/22 09:00 [entrez]
AID - 10.1002/ajh.20852 [doi]
PST - ppublish
SO  - Am J Hematol. 2007 Aug;82(8):725-8. doi: 10.1002/ajh.20852.