PMID- 17373939
OWN - NLM
STAT- MEDLINE
DCOM- 20070607
LR  - 20221207
IS  - 1744-3121 (Print)
IS  - 1744-3121 (Linking)
VI  - 34
IP  - 2
DP  - 2007 Apr
TI  - Polymorphism of HLA class I genes in Meizhou Han population of Guangdong, China.
PG  - 131-6
AB  - Human leukocyte antigen (HLA) is an invaluable marker for anthropological studies 
      because of its extreme polymorphism. Most of the studies carried out in Chinese 
      populations are about HLA class II genes, but few about class I genes. In the 
      present study, we investigated HLA class I polymorphism using polymerase chain 
      reaction-sequencing-based typing (PCR-SBT) method in 104 unrelated Han 
      individuals in Meizhou of Guangdong, southern China. Twenty-three HLA-A, 43 HLA-B 
      and 27 HLA-C alleles were identified and allele frequencies and two-locus (C/B) 
      and three-locus (A/C/B) haplotypes were statistically analysed. The most frequent 
      HLA-A allele is A*110101 with a frequency of 30.3%, followed by A*24020101 
      (22.2%) and A*2420 (11.6%). Among the 43 detected HLA-B alleles, B*5801 (17.0%), 
      B*400101 (15.5%) and B*4601 (10.0%) were frequently observed. Among the 27 
      detected C alleles, the most predominant one is Cw*07020101 (25.8%), followed by 
      Cw*0717 (14.7%). The most frequent HLA-C/B two-locus haplotype is 
      Cw*07020101/B*400101 (10.1%). The most common HLA-A/C/B three-locus haplotype in 
      Meizhou Han is A*110101/Cw*07020101/B*400101 (3.4%). Phylogenetic tree based on 
      HLA class I allele frequencies genetically suggested that Meizhou Han has an 
      affinity to southern Asian populations. The result may also reflect an admixture 
      of Han and ethnic minorities of southern China.
FAU - Chen, S
AU  - Chen S
AD  - State Key Laboratory for Biocontrol, Guangdong Key Laboratory of Pharmaceutical 
      Functional Genes, Department of Biochemistry, College of Life Sciences, Sun 
      Yat-sen (Zhongshan) University, Guangzhou, Guangdong, 510275 China.
FAU - Li, W
AU  - Li W
FAU - Hu, Q
AU  - Hu Q
FAU - Liu, Z
AU  - Liu Z
FAU - Xu, Y
AU  - Xu Y
FAU - Xu, A
AU  - Xu A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Asian People/*ethnology/*genetics
MH  - China/ethnology
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Phylogeny
MH  - *Polymorphism, Genetic
MH  - Population/genetics
EDAT- 2007/03/22 09:00
MHDA- 2007/06/08 09:00
CRDT- 2007/03/22 09:00
PHST- 2007/03/22 09:00 [pubmed]
PHST- 2007/06/08 09:00 [medline]
PHST- 2007/03/22 09:00 [entrez]
AID - EJI669 [pii]
AID - 10.1111/j.1744-313X.2007.00669.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2007 Apr;34(2):131-6. doi: 10.1111/j.1744-313X.2007.00669.x.