PMID- 17374682
OWN - NLM
STAT- MEDLINE
DCOM- 20070504
LR  - 20230216
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 137
IP  - 4
DP  - 2007 Apr
TI  - Starving for life: what animal studies can and cannot tell us about the use of 
      caloric restriction to prolong human lifespan.
PG  - 1078-86
AB  - Caloric restriction (CR) is the only experimental nongenetic paradigm known to 
      increase lifespan. It has broad applicability and extends the life of most 
      species through a retardation of aging. There is considerable interest in the use 
      of CR in humans, and animal studies can potentially tell us about the impacts. In 
      this article we highlight some of the things that animal studies can tell us 
      about CR in humans. Rodent studies indicate that the benefits of CR on lifespan 
      extension are related to the extent of restriction. The benefits of CR, however, 
      decline as the age of onset of treatment is delayed. Modeling these impacts 
      suggests that if a 48-y-old man engaged in 30% CR until his normal life 
      expectancy of 78, he might increase his life expectancy by 2.8 y. Exercise and 
      cold exposure induce similar energy deficits, but animals respond to these energy 
      deficits in different ways that have a minor impact on lifespan. Measurements of 
      animal responses when they cease restriction indicate that prolonged CR does not 
      diminish hunger, even though the animals may have been in long-term energy 
      balance. Neuroendocrine profiles support the idea that animals under CR are 
      continuously hungry. The feasibility of restricting intake in humans for many 
      decades without long-term support is questionable. However, what is unclear from 
      animal studies is whether taking drugs that suppress appetite will generate the 
      same impact on longevity or whether the neuroendocrine correlates of hunger play 
      an integral role in mediating CRs effects.
FAU - Speakman, John R
AU  - Speakman JR
AD  - School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, 
      Scotland, UK. j.speakman@abdn.ac.uk
FAU - Hambly, Catherine
AU  - Hambly C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - *Caloric Restriction
MH  - Eating
MH  - Energy Metabolism
MH  - Humans
MH  - Hunger
MH  - *Longevity
MH  - Time Factors
RF  - 74
EDAT- 2007/03/22 09:00
MHDA- 2007/05/05 09:00
CRDT- 2007/03/22 09:00
PHST- 2007/03/22 09:00 [pubmed]
PHST- 2007/05/05 09:00 [medline]
PHST- 2007/03/22 09:00 [entrez]
AID - S0022-3166(22)09185-4 [pii]
AID - 10.1093/jn/137.4.1078 [doi]
PST - ppublish
SO  - J Nutr. 2007 Apr;137(4):1078-86. doi: 10.1093/jn/137.4.1078.