PMID- 17374712
OWN - NLM
STAT- MEDLINE
DCOM- 20070718
LR  - 20070607
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 92
IP  - 6
DP  - 2007 Jun
TI  - Macrophage infiltration into omental versus subcutaneous fat across different 
      populations: effect of regional adiposity and the comorbidities of obesity.
PG  - 2240-7
AB  - CONTEXT: Macrophage infiltration into adipose tissue has been demonstrated to 
      accompany obesity, with a potential preferential infiltration into intraabdominal 
      vs. sc fat. OBJECTIVE: Our objective was to determine whether this occurs across 
      different populations with a range of body mass indexes and to assess the 
      relationship with regional adiposity and comorbidity of obesity. SETTING AND 
      PATIENTS: In two independent cohorts, we used paired omental (OM) and sc fat 
      biopsies from lean controls or predominantly sc or intraabdominally obese persons 
      with minimal comorbidity (n = 60, cohort 1), or from severely obese women with a 
      significant rate of comorbidity (n = 29, cohort 2). RESULTS: Elevated macrophage 
      infiltration into OM vs. sc fat was observable in lean subjects and exaggerated 
      by obesity, particularly if predominantly intraabdominal. This was paralleled by 
      increased monocyte chemoattractant protein-1 (MCP1) and colony-stimulating 
      factor-1 (CSF1) mRNA levels. Level of CSF1 and MCP1 mRNA correlated with the 
      number of OM macrophages (r = 0.521, P < 0.0001 and r = 0.258, P < 0.051, 
      respectively). In severely obese women (mean body mass index = 43.0 +/- 1.1 
      kg/m(2)), higher protein expression of both MCP1 and CSF1 was detected in OM vs. 
      sc fat. Number of OM macrophages, but not of sc macrophages, correlated with 
      waist circumference (r = 0.636, P = 0.001 vs. r = 0.170, P = 0.427) and with the 
      number of metabolic syndrome parameters (r = 0.385, P = 0.065 vs. r = -0.158, P = 
      0.472, respectively). Preferential macrophage infiltration into OM fat was mainly 
      observed in a subgroup in whom obesity was associated with impaired glucose 
      homeostasis. CONCLUSIONS: Preferential macrophage infiltration into OM fat is a 
      general phenomenon exaggerated by central obesity, potentially linking central 
      adiposity with increased risk of diabetes and coronary heart disease.
FAU - Harman-Boehm, Ilana
AU  - Harman-Boehm I
AD  - Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion 
      University, Beer-Sheva, Israel.
FAU - Bluher, Matthias
AU  - Bluher M
FAU - Redel, Henry
AU  - Redel H
FAU - Sion-Vardy, Netta
AU  - Sion-Vardy N
FAU - Ovadia, Shira
AU  - Ovadia S
FAU - Avinoach, Eliezer
AU  - Avinoach E
FAU - Shai, Iris
AU  - Shai I
FAU - Kloting, Nora
AU  - Kloting N
FAU - Stumvoll, Michael
AU  - Stumvoll M
FAU - Bashan, Nava
AU  - Bashan N
FAU - Rudich, Assaf
AU  - Rudich A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070320
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Body Mass Index
MH  - Cell Movement/immunology
MH  - Chemokine CCL2/genetics
MH  - Cohort Studies
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Macrophage Colony-Stimulating Factor/genetics
MH  - Macrophages/*cytology/immunology
MH  - Male
MH  - Middle Aged
MH  - Obesity/*immunology/*mortality/pathology
MH  - Omentum/*cytology/immunology
MH  - RNA, Messenger/metabolism
MH  - Subcutaneous Fat, Abdominal/*cytology/immunology
EDAT- 2007/03/22 09:00
MHDA- 2007/07/19 09:00
CRDT- 2007/03/22 09:00
PHST- 2007/03/22 09:00 [pubmed]
PHST- 2007/07/19 09:00 [medline]
PHST- 2007/03/22 09:00 [entrez]
AID - jc.2006-1811 [pii]
AID - 10.1210/jc.2006-1811 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2007 Jun;92(6):2240-7. doi: 10.1210/jc.2006-1811. Epub 
      2007 Mar 20.