PMID- 17374994
OWN - NLM
STAT- MEDLINE
DCOM- 20070510
LR  - 20200930
IS  - 1551-4005 (Electronic)
IS  - 1551-4005 (Linking)
VI  - 6
IP  - 6
DP  - 2007 Mar 15
TI  - Oncogenic transformation by the signaling adaptor proteins insulin receptor 
      substrate (IRS)-1 and IRS-2.
PG  - 705-13
AB  - Insulin receptor substrates (IRSs) are adaptor proteins that link signaling from 
      upstream activators to multiple downstream effectors to modulate normal growth, 
      metabolism, survival, and differentiation. Recent cell culture studies have shown 
      that IRSs can interact with, and are functionally required for, the transforming 
      ability of many oncogenes. Consistent with this, IRSs are elevated and 
      hyperactive in many human tumors. IRSs respond to many extracellular signals that 
      are critical for mammary gland development, and we have shown that IRSs disrupt 
      normal mammary acini formation in vitro, and cause mammary tumorigenesis and 
      metastasis in vivo. In this review we will discuss the role of IRSs in both 
      transformation and cancer progression.
FAU - Dearth, Robert K
AU  - Dearth RK
AD  - Breast Center, Department of Medicine, Baylor College of Medicine, Houston, 
      Texas, USA.
FAU - Cui, Xiaojiang
AU  - Cui X
FAU - Kim, Hyun-Jung
AU  - Kim HJ
FAU - Hadsell, Darryl L
AU  - Hadsell DL
FAU - Lee, Adrian V
AU  - Lee AV
LA  - eng
GR  - CA90221/CA/NCI NIH HHS/United States
GR  - CA94118/CA/NCI NIH HHS/United States
GR  - DK07696/DK/NIDDK NIH HHS/United States
GR  - DK52197/DK/NIDDK NIH HHS/United States
GR  - P01CA30195/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20070320
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - 0 (IRS1 protein, human)
RN  - 0 (IRS2 protein, human)
RN  - 0 (Insulin Receptor Substrate Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Cell Transformation, Neoplastic/genetics/*metabolism/*pathology
MH  - Disease Progression
MH  - Humans
MH  - Insulin Receptor Substrate Proteins
MH  - Intracellular Signaling Peptides and Proteins/*physiology
MH  - Phosphoproteins/*physiology
MH  - Proto-Oncogene Proteins/*physiology
RF  - 153
EDAT- 2007/03/22 09:00
MHDA- 2007/05/11 09:00
CRDT- 2007/03/22 09:00
PHST- 2007/03/22 09:00 [pubmed]
PHST- 2007/05/11 09:00 [medline]
PHST- 2007/03/22 09:00 [entrez]
AID - 4035 [pii]
AID - 10.4161/cc.6.6.4035 [doi]
PST - ppublish
SO  - Cell Cycle. 2007 Mar 15;6(6):705-13. doi: 10.4161/cc.6.6.4035. Epub 2007 Mar 20.